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New Candidaspongiolides, Tedanolide Analogues That Selectively Inhibit Melanoma Cell Growth

  1. Author:
    Whitson, E. L.
    Pluchino, K. M.
    Hall, M. D.
    McMahon, J. B.
    McKee, T. C.

  2. Author Address

    [Whitson, EL; McMahon, JB; Mckee, TC] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA [Pluchino, KM; Hall, MD] NCI, Cell Biol Lab, Ctr Canc Res, Bethesda, MD 20892 USA;NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA;mckeeta@mail.nih.gov
    1. Year: 2011
    2. Date: Jul
  2. Journal: Organic Letters
    1. 13
    2. 13
    3. Pages: 3518-3521
  4. Type of Article: Article
  5. ISSN: 1523-7060
  1. Abstract:

    Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines.

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External Sources

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  2. DOI: 10.1021/ol201329p
  3. View record in Web of Science®
  4. WOS: 000291920800059

Library Notes

  1. Fiscal Year: FY2010-2011
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