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Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance

  1. Author:
    Hodge, J. N.
    Srinivasula, S.
    Hu, Z. H.
    Read, S. W.
    Porter, B. O.
    Kim, I.
    Mican, J. M.
    Paik, C.
    DeGrange, P.
    Di Mascio, M.
    Sereti, I.

  2. Author Address

    [Sereti, I] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH,Div Intramural Res, Bethesda, MD 20892 USA. [Srinivasula, S] SAIC Frederick Inc, Biostat Res Branch, NCI Frederick, Frederick, MD USA. [Hu, ZH] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA. [Read, SW] NIAID, Div Aids, Bethesda, MD 20892 USA. [Kim, I] SAIC Frederick Inc, Appl Dev Res Directorate, Frederick, MD USA. [Mican, JM] NIAID, Div Clin Res, Bethesda, MD 20892 USA. [Paik, C] Ctr Clin, Radiopharmaceut Lab, Bethesda, MD USA. [DeGrange, P] NIAID Frederick, Battelle Charles River Integrated Res Facil, NIH, Bethesda, MD USA.;Sereti, I (reprint author), NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH,Div Intramural Res, 10 Ctr Dr,Bldg 10,Rm 11B07A, Bethesda, MD 20892 USA;isereti@niaid.nih.gov
    1. Year: 2011
    2. Date: Sep
  2. Journal: Blood
    1. 118
    2. 12
    3. Pages: 3244-3253
  4. Type of Article: Article
  5. ISSN: 0006-4971
  1. Abstract:

    IL-7 is essential for T-cell homeostasis. Elevated serum IL-7 levels in lymphopenic states, including HIV infection, are thought to be due to increased production by homeostatic feedback, decreased receptor-mediated clearance, or both. The goal of this study was to understand how immune reconstitution through antiretroviral therapy (ART) in HIV(+) patients affects IL-7 serum levels, expression of the IL-7 receptor (CD127), and T-cell cycling. Immunophenotypic analysis of T cells from 29 HIV(-) controls and 43 untreated HIV(+) patients (30 of whom were followed longitudinally for <= 24 months on ART) was performed. Restoration of both CD4(+) and CD8(+) T cells was driven by increases in CD127(+) naive and central memory T cells. CD4(+) T-cell subsets were not fully restored after 2 years of ART, whereas serum IL-7 levels normalized by 1 year of ART. Mathematical modeling indicated that changes in serum IL-7 levels could be accounted for by changes in the receptor concentration. These data suggest that T-cell restoration after ART in HIV infection is driven predominantly by CD127(+) cells and that decreases of serum IL-7 can be largely explained by improved CD127-mediated clearance. (Blood. 2011;118(12):3244-3253)

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External Sources

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  2. DOI: 10.1182/blood-2010-12-323600
  3. View record in Web of Science®
  4. WOS: 000295120900011

Library Notes

  1. Fiscal Year: FY2011-2012
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