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Chlorinated Englerins with Selective Inhibition of Renal Cancer Cell Growth

  1. Author:
    Akee, R. K.
    Ransom, T.
    Ratnayake, R.
    McMahon, J. B.
    Beutler, J. A.

  2. Author Address

    [Ransom, Tanya; Ratnayake, Ranjala; McMahon, James B.; Beutler, John A.] NCI, Mol Targets Lab, Mol Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA. [Akee, Rhone K.] SAIC Frederick Natl Canc Inst, Nat Prod Support Grp, Frederick, MD 21702 USA.;Beutler, JA (reprint author), NCI, Mol Targets Lab, Mol Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA;beutlerj@mail.nih.gov
    1. Year: 2012
    2. Date: Mar
  2. Journal: Journal of Natural Products
    1. 75
    2. 3
    3. Pages: 459-463
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1).

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External Sources

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  2. DOI: 10.1021/np200905u
  3. View record in Web of Science®
  4. WOS: 000301810700019

Library Notes

  1. Fiscal Year: FY2011-2012
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