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A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population

  1. Author:
    Tan, A. H.
    Sun, J. L.
    Xia, N.
    Qin, X.
    Hu, Y. L.
    Zhang, S. J.
    Tao, S.
    Gao, Y.
    Yang, X. B.
    Zhang, H. Y.
    Kim, S. T.
    Peng, T.
    Lin, X. L.
    Li, L.
    Mo, L. J.
    Liang, Z. J.
    Shi, D. Y.
    Huang, Z.
    Huang, X. H.
    Liu, M.
    Ding, Q.
    Trent, J. M.
    Zheng, S. L.
    Mo, Z. N.
    Xu, J. F.

  2. Author Address

    [Tan, Aihua; Qin, Xue; Hu, Yanling; Zhang, Shijun; Gao, Yong; Yang, Xiaobo; Zhang, Haiying; Mo, Zengnan] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China. [Hu, Yanling; Li, Li] Guangxi Med Univ, Med Sci Res Ctr, Nanning 530021, Guangxi, Peoples R China. [Yang, Xiaobo; Zhang, Haiying] Guangxi Med Univ, Dept Occupat Hlth & Environm Hlth, Sch Publ Hlth, Nanning 530021, Guangxi, Peoples R China. [Sun, Jielin; Kim, Seong-Tae; Zheng, S. Lilly; Xu, Jianfeng] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC 27157 USA. [Xia, Ning] Guangxi Med Univ, Affiliated Hosp 1, Ctr Metab Dis & Diabet, Nanning 530021, Guangxi, Peoples R China. [Qin, Xue] Guangxi Med Univ, Affiliated Hosp 1, Dept Clin Lab, Nanning 530021, Guangxi, Peoples R China. [Peng, Tao] Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Nanning 530021, Guangxi, Peoples R China. [Mo, Linjian; Mo, Zengnan] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning 530021, Guangxi, Peoples R China. [Tao, Sha; Trent, Jeffrey M.; Xu, Jianfeng] Van Andel Res Inst, Ctr Genet Epidemiol, Grand Rapids, MI 49503 USA. [Gao, Yong; Lin, Xiaoling; Xu, Jianfeng] Fudan Univ, Sch Life Sci, Fudan VARI Ctr Genet Epidemiol, Shanghai 200433, Peoples R China. [Peng, Tao] NCI, Lab Genom Divers, NIH, Frederick, MD 21702 USA. [Liang, Zhengjia; Shi, Deyi; Huang, Zhang] Fangchenggang First Peoples Hosp, Med Examinat Ctr, Fangchenggang 538021, Guangxi, Peoples R China. [Huang, Xianghua] Guigang Peoples Hosp, Med Examinat Ctr, Guigang 537100, Guangxi, Peoples R China. [Liu, Ming] Yulin First Peoples Hosp, Med Examinat Ctr, Yulin 537000, Guangxi, Peoples R China. [Ding, Qiang; Xu, Jianfeng] Fudan Univ, Huashan Hosp, Fudan Univ Inst Urol, Shanghai 200040, Peoples R China.;Mo, ZN (reprint author), Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China;zengnanmo@hotmail.com
    1. Year: 2012
    2. Date: Apr
  2. Journal: Human Molecular Genetics
    1. 21
    2. 7
    3. Pages: 1658-1664
  4. Type of Article: Article
  5. ISSN: 0964-6906
  1. Abstract:

    Triglyceride (TG) is a complex phenotype influenced by both genetic and environmental factors. Recent genome-wide association studies (GWAS) have identified genes or loci affecting lipid levels; however, such studies in Chinese populations are limited. A two-stage GWAS were conducted to identify genetic variants that were associated with TG in a Chinese population of 3495 men. Geneenvironment interactions on serum TG levels were further investigated for the seven single nucleotide polymorphisms (SNPs) that were studied in both stages. Two previously reported SNPs (rs651821 in APOA5, rs328 in LPL) were replicated in the second stage, and the combined P-values were 9.19 10(26) and 1.41 10(9) for rs651821 and rs328, respectively. More importantly, a significant interaction between aldehyde dehydrogenase 2 (ALDH2) rs671 and alcohol consumption on serum TG levels were observed (P 3.34 10(5)). Rs671 was significantly associated with serum TG levels in drinkers (P 1.90 10(10)), while no association was observed in non-drinkers (P 0.05). For drinkers, men carrying the AA/AG genotype have significantly lower serum TG levels, compared with men carrying the GG genotype. For men with the GG genotype, the serum TG levels increased with the quantity of alcohol intake (P 1.28 10(8) for trend test). We identified a novel, significant interaction effect between alcohol consumption and the ALDH2 rs671 polymorphism on TG levels, which suggests that the effect of alcohol intake on TG occurs in a two-faceted manner. Just one drink can increase TG level in susceptible individuals who carry the GG genotype, while individuals carrying AA/AG genotypes may actually benefit from moderate drinking.

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External Sources

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  2. DOI: 10.1093/hmg/ddr587
  3. View record in Web of Science®
  4. WOS: 000301299700019

Library Notes

  1. Fiscal Year: FY2011-2012
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