Skip NavigationSkip to Content
Return Return to Search Results

Pathogenesis: disease mechanisms in humans and animal models the human genes that limit AIDS

  1. Author:
    O'Brien, S.
    Dean, M.
    Carrington, M.
    Winkler, C.
    Smith, M.
    Nelson, G.
    Stephens, J. C.
    1. Year of Conference: 1999
  2. Conference Name: Conference on Retroviruses and Opportunistic Infections
    1. Pages: 214 (abstract no. S14)
  4. Type of Work: Meeting Abstract
  1. Abstract:

    The development of AIDS symptoms is a gradual but deliberate process whereby a virulent swarm of HIV-1 genomes replicate in macrophages, monocytes, and T-cells challenging the immune system to its extreme. The cellular compartments and machinery that facilitate the process are human gene products which are punctuated by abundant allelic variation that insome cases determines the efficiency and kinetics of disease progression. Using high-throughput molecular genetic typing of epidemiologic cohorts of HIV-1-infected study participants, we have searched for host genetic variants in genes whose products participate in viral replication. To date we have discovered attributable genetic influence on HIV-1 infection, disease progression, and AIDS sequelae involving coding and promoter regions of several human genes, namely CCR5, CCR2, SDF1, HLA Class I. My presentation will discuss the discovery, characterization and functioning of the multi-genic influences on the outcomes of HIV-1 infection and the pattern of the epidemic.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel