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Effects of plasma HIV RNA, CD4(+) T lymphocytes, and the chemokine receptors CCR5 and CCR2b on HIV disease progression in hemophiliacs

  1. Author:
    Daar, E. S.
    Lynn, H.
    Donfield, S.
    Gomperts, E.
    Hilgartner, M. W.
    Hoots, K.
    Chernoff, D.
    Winkler, C.
    O'Brien, S. J.

  2. Author Address

    Daar ES Cedars Sinai Med Ctr, Div Infect Dis B217,8700 Beverly Blvd Los Angeles, CA 90048 USA Cedar Sinai Burns & Allen Res Inst, Div Infect Dis, Dept Med Los Angeles, CA USA Univ Calif Los Angeles, Sch Med Los Angeles, CA USA Rho Inc Chapel Hill, NC USA Childrens Hosp Los Angeles Los Angeles, CA 90027 USA New York Hosp, Cornell Med Ctr, Div Pediat Hematol & Oncol New York, NY 10021 USA Univ Texas, Sch Med, Dept Pediat Houston, TX USA Univ Texas, Sch Med, Dept Internal Med Houston, TX USA Chiron Corp Emeryville, CA 94608 USA Sci Applicat Int Corp Frederick, MD USA NCI, Frederick Canc Res & Dev Ctr, Intramural Res Support Program, SAIC Frederick Frederick, MD USA NCI, Lab Genom Divers Frederick, MD 21701 USA
    1. Year: 1999
  2. Journal: Jaids-Journal of Acquired Immune Deficiency Syndromes
    1. 21
    2. 4
    3. Pages: 317-325
  4. Type of Article: Article
  1. Abstract:

    We have investigated the effects of plasma HIV RNA, CD4(+) T lymphocytes and chemokine receptors CCR5 and CCR2b on HIV disease progression in hemophiliacs. We prospectively observed during follow-up 207 HIV-infected hemophiliacs in the Hemophilia Growth and Development Study. Plasma HIV RNA was measured on cryopreserved plasma from enrollment using the Chiron Corporation bDNA (version 2.0) assay. Genoytpe variants CCR2b-64I and CCR5-Delta 32 were detected using standard molecular techniques. Those with the mutant allele for CCR2b, and to a lesser extent CCR5, had lower plasma HIV RNA, and higher CD4(+) T lymphocytes than did those without these genetic variants. After controlling for the effects of plasma HIV RNA and CD4(+) T lymphocytes, those with the CCR2b mutant allele compared with those wild-type, had a trend toward a lower risk of progression to AIDS, adjusted relative hazard of 1.94 (95% confidence interval [CI], 0.9-4.18; p = .092), and AIDS-related death, relative hazard 1.97 (95% CI, 0.98-4.00; p = .059). We conclude that plasma HIV RNA, CD4(+) T lymphocytes, and CCR genotypes are correlated, and the protective affect of CCR2b against HIV disease progression is not completely explained by plasma HIV RNA or CD4(+) T-lymphocyte number. [References: 44]

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