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Sickle Cell Trait and the Risk of ESRD in Blacks

  1. Author:
    Naik, Rakhi P.
    Irvin, Marguerite R.
    Judd, Suzanne
    Gutierrez, Orlando M.
    Zakai, Neil A.
    Derebail, Vimal K.
    Peralta, Carmen
    Lewis, Michael R.
    Zhi, Degui
    Arnett, Donna
    McClellan, William
    Wilson, James G.
    Reiner, Alexander P.
    Kopp, Jeffrey B.
    Winkler, Cheryl
    Cushman, Mary

  2. Author Address

    Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA.Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA.Univ Vermont, Dept Med, Larner Coll Med, Burlington, VT USA.Univ Vermont, Dept Pathol & Lab Med, Larner Coll Med, Burlington, VT USA.Univ North Carolina Chapel Hill, Univ North Carolina Kidney Ctr, Dept Med, Div Nephrol & Hypertens, Chapel Hill, NC USA.Univ Calif San Francisco, Dept Med, San Francisco Vet Affairs Med Ctr, San Francisco, CA USA.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA.Emory Univ, Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.NIDDK, Kidney Dis Branch, NIH, Bethesda, MD USA.NCI, Basic Res Lab, Leidos Biomed Res, Frederick Natl Lab, Frederick, MD 21701 USA.
    1. Year: 2017
    2. Date: Jul 1
  2. Journal: Journal of the American Society of Nephrology
  3. AMER SOC NEPHROLOGY,
    1. 28
    2. 7
    3. Pages: 2180-2187
  5. Type of Article: Article
  6. ISSN: 1046-6673
  1. Abstract:

    Blacks, compared with whites, have an increased risk of progression to end-stage renal disease (ESRD). Emerging evidence suggests that, in addition to APOL1 high-risk genotypes, hemoglobin variants, including sickle cell trait (SCT) and hemoglobin C trait, have a role in kidney disease in blacks. However, the association between these hemoglobin traits and ESRD remains unknown. In a large population-based cohort, the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, we evaluated 9909 self-reported blacks (739 with SCT and 243 with hemoglobin C trait). Incident ESRD occurred in 40 of 739 (5.4%) individuals with SCT, six of 243 (2.5%) individuals with hemoglobin C trait, and 234 of 8927 (2.6%) noncarriers. The incidence rate for ESRD was 8.5 per 1000 person-years for participants with SCT and 4.0 per 1000 person-years for noncarriers. Compared with individuals without SCT, individuals with SCT had a hazard ratio for ESRD of 2.03 (95% confidence interval, 1.44 to 2.84). Hemoglobin C trait did not associate with prevalent CKD or ESRD. The incidence rate for ESRD among participants with APOL1 high-risk genotypes was 6.6 per 1000 person-years, with a hazard ratio for ESRD of 1.77 (95% confidence interval, 1.31 to 2.38) for participants with, compared with those without, APOL1 high-risk genotypes. In this cohort, SCT strongly associated with risk of progression to ESRD in blacks, and this degree of risk for ESRD was similar to that conferred by APOL1 high-risk genotypes. These results may have important public policy implications for genetic counseling of SCT carriers.

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External Sources

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  2. DOI: 10.1681/ASN.2016101086
  3. PMID: 28280138
  4. View record in Web of Science®
  5. WOS: 000404568700023

Library Notes

  1. Fiscal Year: FY2016-2017
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