Skip NavigationSkip to Content
Return Return to Search Results

Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu 1A (Ap1m1) and mu 1B (Ap1m2)

  1. Author:
    Nakatsu, F.
    Kadohira, T.
    Gilbert, D. J.
    Jenkins, N. A.
    Kakuta, H.
    Copeland, N. G.
    Saito, T.
    Ohno, H.

  2. Author Address

    Ohno H Kanazawa Univ, Inst Canc Res, Div Mol Membrane Biol 13-1 Takaramachi Kanazawa Ishikawa 9200934 Japan Kanazawa Univ, Inst Canc Res, Div Mol Membrane Biol Kanazawa Ishikawa 9200934 Japan Chiba Univ, Grad Sch Med, Dept Mol Genet Chiba Japan NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD USA
    1. Year: 1999
  2. Journal: Cytogenetics and Cell Genetics
    1. 87
    2. 1-2
    3. Pages: 53-58
  4. Type of Article: Article
  1. Abstract:

    The protein mu 1B is a member of the medium chain family of the clathrin-associated adaptor complex and is expressed exclusively in epithelial cells. We determined the genomic structure of previously cloned murine genes for mu 1B (Ap1m2) and its closely related homolog, mu 1A (Ap1m1). Comparison of their genomic structures revealed that the positions of introns are identical between these two genes, except for the insertion of an additional intron in Ap1m1 (intron 4). By contrast, these structures are different from that of the more distantly related Ap2m1 gene encoding mu 2. Taken together with the similarity of amino acid sequences among these genes, the data presented in this study suggest that Ap1m1/2 and Ap2m1 diverged long before the separation of Ap1m1 and Ap1m2, which most likely resulted from a relatively recent gene duplication. We also mapped AP1M2 to human chromosome 19p13.2 and Ap1m2 to the proximal region of mouse chromosome 9. The results are consistent with the fact that these regions are syntenic. Copyright (C) 1999 S. Karger AG, Basel. [References: 27]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel