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Xenodiagnosis Using Ixodes scapularis Larval Ticks in Humans

  1. Author:
    Turk, Siu-Ping
    Williams, Carla
    Marques, Adriana

  2. Author Address

    Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive BG 10 RM 12C118 MSC 1899, Bethesda, MD, 20892-1899, USA., Leidos Biomedical Research, Inc., NCI-Frederick, Frederick, MD, 21702, USA., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive BG 10 RM 12C118 MSC 1899, Bethesda, MD, 20892-1899, USA. amarques@niaid.nih.gov.,
    1. Year: 2018
  2. Journal: Methods in molecular biology (Clifton, N.J.)
    1. 1690
    2. Pages: 337-346
  4. Type of Article: Article
  1. Abstract:

    Xenodiagnosis is the use of a natural vector to detect the presence of an organism, and xenodiagnosis using Ixodes ticks has long been used by entomologists in Lyme disease research to provide evidence of the host 39;s infectious status with Borrelia burgdorferi. We developed the methodology and performed the first human research study using uninfected larval Ixodes scapularis ticks to assess evidence of B. burgdorferi infection. Here, we describe in detail the methodology used for the procedure. Xenodiagnosis using Ixodes ticks in humans remains an experimental method and must be performed under an approved clinical research protocol.

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  2. DOI: 10.1007/978-1-4939-7383-5_26
  3. PMID: 29032557

Library Notes

  1. Fiscal Year: FY2017-2018
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