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Quantification of regional aerosol deposition patterns as a function of aerodynamic particle size in rhesus macaques using PET/CT imaging

  1. Author:
    Dabisch, P A [ORCID]
    Xu, Z
    Boydston, J A
    Solomon, Jeffrey
    Bohannon, J K [ORCID]
    Yeager, J J
    Taylor, J R
    Reeder, R J
    Sayre, P [ORCID]
    Seidel, J
    Mollura, D J
    Hevey, M C
    Jahrling, P B [ORCID]
    Lackemeyer, M G [ORCID]

  2. Author Address

    a Battelle National Biodefense Institute for the US Department of Homeland Security , National Biodefense Analysis and Countermeasures Center , Frederick , MD , USA., b Center for Disease Imaging, Radiology, and Imaging Services , National Institutes of Health , Bethesda , MD , USA., c Clinical Research Directorate/Clinical Monitoring Research Program , Leidos Biomedical Research, Inc., NCI Campus at Frederick , Frederick , MD , USA., d Integrated Research Facility , National Institute of Allergy and Infectious Disease (NIAID) , Frederick , MD , USA.,
    1. Year: 2017
    2. Date: Dec 11
    3. Epub Date: 2017 12 11
  2. Journal: Inhalation toxicology
    1. 29
    2. 11
    3. Pages: 506-515
  4. Type of Article: Article
  5. ISSN: 0895-8378
  1. Abstract:

    Aerosol aerodynamic particle size is known to affect deposition patterns of inhaled aerosol particles, as well as the virulence of inhaled bioaerosol particles. While a significant amount of work has been performed to describe the deposition of aerosol particles in the human respiratory tract, only a limited amount of work has been performed to describe the deposition of aerosol particles in the respiratory tract of nonhuman primates, an animal model commonly utilized in pharmacological and toxicological studies, especially in the biodefense field. In this study, anesthetized rhesus macaques inhaled radiolabeled aerosols with MMADs of 1.7, 3.6, 7.4 and 11.8? 181;m to characterize regional deposition patterns. The results demonstrate that the regional deposition pattern shifts as particle size increases, with greater deposition in more proximal regions of the respiratory tract and decreased deposition in the pulmonary region. The results of this study extend the findings of previous studies which demonstrated a similar shift in the deposition pattern as a function of particle size by providing greater resolution of deposition patterns. These data on regional deposition patterns provide a starting point to begin to explore potential mechanisms responsible for the differences in virulence of infectious bioaerosols as a function of particle size and deposition pattern reported in previous studies. Additionally, the data are useful to assess the performance of various deposition models that have been published in the literature.

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External Sources

  1. View Full Text
  2. DOI: 10.1080/08958378.2017.1409848
  3. PMID: 29224407
  4. View record in Web of Science®
  5. WOS: 000423280200004

Library Notes

  1. Fiscal Year: FY2017-2018
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