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Chemokine and chemokine receptor gene variants and risk of non-Hodgkin's lymphoma in human immunodeficiency virus-1-infected individuals

  1. Author:
    Rabkin, C. S.
    Yang, Q.
    Goedert, J. J.
    Nguyen, G.
    Mitsuya, H.
    Sei, S.

  2. Author Address

    Rabkin CS NCI, Viral Epidemiol Branch MSC 7248 Bethesda, MD 20892 USA NCI, Viral Epidemiol Branch Bethesda, MD 20892 USA NCI, HIV & AIDS Malignancy Branch Bethesda, MD 20892 USA NCI, Expt Retrovirol Sect Bethesda, MD 20892 USA NCI, Sci Applicat Int Corp, HIV Clin Interface Lab Frederick, MD 21701 USA Kumamoto Univ, Sch Med, Dept Internal Med 2 Kumamoto 860 Japan
    1. Year: 1999
  2. Journal: Blood
    1. 93
    2. 6
    3. Pages: 1838-1842
  4. Type of Article: Article
  1. Abstract:

    Normal B-lymphocyte maturation and proliferation are regulated by chemotactic cytokines (chemokines), and genetic polymorphisms in chemokines and chemokine receptors modify progression of human immunodeficiency virus-1 (HIV-1) infection. Therefore, 746 HIV-1-infected persons were examined for associations of previously described stromal cell-derived factor 1 (SDF-1) chemokine and CCR5 and CCR2 chemokine receptor gene variants with the risk of B-cell non-Hodgkin's lymphoma (NHL). The SDF1-3'A chemokine variant, which is carried by 37% of whites and 11% of blacks, was associated with approximate doubling of the NHL risk in heterozygotes and roughly a fourfold increase in homozygotes. After a median follow-up of 11.7 years, NHL developed in 6 (19%) of 30 SDF1-3'A/3'A homozygotes and 22 (10%) of 202 SDF1-+/3'A heterozygotes, compared with 24 (5%) of 514 wild-type subjects. The acquired immunodeficiency syndrome (AIDS)-protective chemokine receptor variant CCR5-Delta 32 was highly protective against NHL, whereas the AIDS-protective variant CCR2-641 had no significant effect, Racial differences in SDF1-3'A frequency may contribute to the lower risk of HIV-1-associated NHL in blacks compared with whites. SDF-1 genotyping of HIV-1-infected patients may identify subgroups warranting enhanced monitoring and targeted interventions to reduce the risk of NHL. This is a US government work. There are no restrictions on its use. [References: 32]

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