Skip NavigationSkip to Content
Return Return to Search Results

An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer

  1. Author:
    Asampille, Gitanjali
    Verma, Brijesh Kumar
    Swain, Monalisa
    Shettar, Abhijith
    Rosenzweig, Steven A
    Kondaiah, Paturu
    Atreya, Hanudatta S

  2. Author Address

    NMR Research Centre, Indian Institute of Science, Bangalore, 560012, India., Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore, 560012, India., Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India., Basic Research Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Biotechnology Engineering, Ramaiah Institute of Technology, Bangalore, Karnataka, 560054, India., Department of Cell and Molecular Pharmacology, & Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, 29425, USA., Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India. paturu@iisc.ac.in., NMR Research Centre, Indian Institute of Science, Bangalore, 560012, India. hsatreya@iisc.ac.in.,
    1. Year: 2018
    2. Date: Dec 08
    3. Epub Date: 2018 12 08
  2. Journal: Journal of nanobiotechnology
    1. 16
    2. 1
    3. Pages: 101
  4. Type of Article: Article
  5. Article Number: 101
  6. ISSN: 1477-3155
  1. Abstract:

    We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface. While the nanotubes are non-toxic towards cells in general, they can be loaded with suitable drugs to be released in a sustained manner in cancer cells. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye. They are stable over a wide range of temperature due to intermolecular disulphide bonds formed during the self-assembly process. At the same time, presence of disulphide bonds provides a redox molecular switch for their degradation. Taken together this system provides a unique avenue for multimodal formulation in cancer therapy.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1186/s12951-018-0427-1
  3. PMID: 30526620
  4. View record in Web of Science®
  5. WOS: 000452715300001
  6. PII : 10.1186/s12951-018-0427-1

Library Notes

  1. Fiscal Year: FY2018-2019
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel