Skip NavigationSkip to Content
Return Return to Search Results

New class I and IIHLA alleles strongly associated with opposite patterns of progression to AIDS

  1. Author:
    Hendel, H.
    Caillat-Zucman, S.
    Lebuanec, H.
    Carrington, M.
    O'Brien, S.
    Andrieu, J. M.
    Schachter, F.
    Zagury, D.
    Rappaport, J.
    Winkler, C.
    Nelson, G. W.
    Zagury, J. F.

  2. Author Address

    Zagury JF Univ Paris 06, Lab Physiol Cellulaire 4 Pl Jussieu F-75005 Paris France Univ Paris 06, Lab Physiol Cellulaire F-75005 Paris France Hop Necker Enfants Malad, Immunol Lab Paris France NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Intramural Res Support Program Frederick, MD 21702 USA NCI, Lab Genomic Divers Ft Detrick, MD 21702 USA Hop Laennec, Serv Cancerol, SIDA F-75340 Paris France MCP Hahnemann Univ Hlth Sci, Ctr Neurovirol & Neurooncol Philadelphia, PA 19102 USA
    1. Year: 1999
  2. Journal: Journal of Immunology
    1. 162
    2. 11
    3. Pages: 6942-6946
  4. Type of Article: Article
  1. Abstract:

    The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid progressors to AIDS corresponding to the extremes of HIV disease outcome of 20,000 Caucasians of European descent. A comprehensive analysis of HLA class I and class II genes in this highly informative cohort has identified HLA alleles associated with fast or slow progression, including several not described previously. A quantitative analysis shows an overall HLA influence independent of and equal in magnitude (for the protective effect) to the effect of the CCR5-Delta 32 mutation. Among HLA class I genes, A29 (p = 0.001) and B22 (p < 0.0001) are significantly associated with rapid progression, whereas B14 (p = 0.001) and C8 (p = 0.004) are significantly associated with nonprogression, The class I alleles B27, B57, C14 (protective), and C16, as well as B35 (susceptible), are also influential, but their effects are less robust. Influence of class II alleles was only observed for DR11, These results confirm the influence of the immune system on disease progression and may have implications on peptide-based vaccine development. [References: 34]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel