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Risk factors for Kaposi's sarcoma associated herpesvirus (KSHV) DNA in blood and in saliva in rural Uganda

  1. Author:
    Nalwoga, Angela
    Nakibuule, Marjorie
    Marshall,Vickie
    Miley,Wendell
    Labo, Nazzarena
    Cose, Stephen
    Whitby,Denise
    Newton, Robert
  2. Author Address

    MRC/UVRI and LSHTM Uganda Research Unit, Entebbe; Uganda., London School of Hygiene & Tropical Medicine, London; United Kingdom., Viral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD; United States of America.,
    1. Year: 2019
    2. Date: Sep 26
    3. Epub Date: 2019 09 26
  1. Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    1. 71
    2. 4
    3. Pages: 1055-1062
  2. Type of Article: Article
  3. ISSN: 1058-4838
  1. Abstract:

    Detectable KSHV DNA in blood and increased antibody titres may indicate KSHV reactivation, while transmission of KSHV occurs via viral shedding in saliva. We investigated risk factors for KSHV DNA detection by real-time PCR, in blood and viral shedding in saliva, in 878 people aged 3 to 89 years of both sexes in a rural Ugandan population cohort. Helminths were detected using microscopy and malaria parasitaemia was identified using rapid diagnostic tests. Regression modelling was used for statistical analysis. and discussion: KSHV viral load in blood did not correlate with viral load in saliva, suggesting separate immunological control within each compartment. The proportion of individuals with detectable virus in blood was 23% among children aged 3-5 years , 22% among 6-12 years old, thereafter reducing with increasing age. The proportion of individuals with detectable virus in saliva increased from 30% in 3-5 year old children to 45% in those aged 6-12 and decreasing subsequently with increasing age. Overall, 29% of males shed in saliva compared to 19% of females (p = 0.008). Together, these data suggest that young males may be responsible for much of the onward transmission of KSHV. Individuals with a current malaria infection had higher levels of viral DNA in blood (p = 0.031) compared to malaria uninfected individuals. This suggests that malaria may lead to KSHV reactivation, thereby increasing transmission and pathogenicity of the virus. © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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External Sources

  1. DOI: 10.1093/cid/ciz916
  2. PMID: 31555829
  3. WOS: 000577168700022
  4. PII : 5573921

Library Notes

  1. Fiscal Year: FY2019-2020
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