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Rapid telomere shortening in children

  1. Author:
    Zeichner, S. L.
    Palumbo, P.
    Feng, Y. R.
    Xiao, X. D.
    Gee, D.
    Sleasman, J.
    Goodenow, R.
    Biggar, R.
    Dimitrov, D.

  2. Author Address

    Zeichner SL NCI, HIV & AIDS Malignancy Branch, NIH Bldg 10,Room 13N240 Bethesda, MD 20892 USA NCI, HIV & AIDS Malignancy Branch, NIH Bethesda, MD 20892 USA Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Pediat Newark, NJ 07103 USA NCI, Lab Expt & Computat Biol Frederick, MD USA Univ Florida, Dept Pediat Gainesville, FL USA NCI, Viral Epidemiol Branch Bethesda, MD 20892 USA
    1. Year: 1999
  2. Journal: Blood
    1. 93
    2. 9
    3. Pages: 2824-2830
  4. Type of Article: Article
  1. Abstract:

    Telomere shortening may reflect the total number of divisions experienced by a somatic cell and is associated with replicative senescence. We found that the average rate of telomere shortening in peripheral blood mononuclear cells (PBMCs) obtained longitudinally from nine different infants during the first 3 years of life (270 bp per year) is more than fourfold higher than in adults and does not correlate with telomerase activity, These results show that the rate of telomere loss changes during ontogeny, suggesting the existence of periods of accelerated cell division, Because human immunodeficiency virus (HIV) preferentially infects actively dividing cells, our observation suggesting accelerated cell division in children may provide an explanation for some of the distinctive pathogenic features of the HIV disease in infants, including higher viral loads and more rapid progression to acquired immunodeficiency syndrome (AIDS). This is a US government work. There are no restrictions on its use. [References: 30]

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