Skip NavigationSkip to Content
Return Return to Search Results

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

  1. Author:
    Morales, J.
    Homey, B.
    Vicari, A. P.
    Hudak, S.
    Oldham, E.
    Hedrick, J.
    Orozco, R.
    Copeland, N. G.
    Jenkins, N. A.
    McEvoy, L. M.
    Zlotnik, A.

  2. Author Address

    Zlotnik A DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol 901 Calif Ave Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol Palo Alto, CA 94304 USA Schering Plough, Lab Immunol Res Dardilly France Schering Plough Corp, Res Inst, Human Genome Res Kenilworth, NJ 07033 USA Inst Nacl Nutr Mexico City DF Mexico NCI, Mammalian Genet Lab, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 96
    2. 25
    3. Pages: 14470-14475
  4. Type of Article: Article
  1. Abstract:

    In contrast to naive lymphocytes, memory/effector lymphocytes can access nonlymphoid effector sires and display restricted, often tissue-selective, migration behavior. The cutaneous lymphocyte-associated antigen (CLA) defines a subset of circulating memory T cells that selectively localize in cutaneous sites mediated in part: by the interaction of CLA with its vascular ligand E-selectin. Here, we report the identification and characterization of a CC chemokine, cutaneous T cell-attracting chemokine (CTACK), Both human and mouse CTACK are detected only in skin by Southern and Northern blot analyses. Specifically, CTACK message is found in the mouse epidermis and in human keratinocytes, and anti-CTACK mAbs predominantly stain the epithelium. Finally, CTACK selectively attracts CLA(+) memory T cells. Taken together, these results suggest an important role for CTACK in recruitment of CLA(+) T cells to cutaneous sites. CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes. [References: 28]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel