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APOL1 Nephropathy Risk Alleles and Risk of Sepsis in Blacks

  1. Author:
    Chaudhary, Ninad S [ORCID]
    Moore, Justin X
    Zakai, Neil A
    Judd, Suzanne E
    Naik, Rakhi P
    Limou, Sophie
    Cushman, Mary
    Lange, Leslie A
    Wang, Henry E
    Winkler,Cheryl [ORCID]
    Irvin, Marguerite R
    Kopp, Jeffrey B
    Gutiérrez, Orlando M

  2. Author Address

    Departments of Epidemiology., Division of Public Health Sciences, Department of Surgery, Washington University, St. Louis, Missouri., Departments of Medicine and Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont., Biostatistics, and., Department of Medicine, Johns Hopkins University, Baltimore, Maryland., Nantes University, French National Institute of Health and Medical Research, Center for Research in Transplantation and Immunology, Nantes, France., Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Department of Emergency Medicine, University of Texas Health Science Center at Houston, Houston, Texas., Basic Research Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland; and., Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland ogutierrez@uabmc.edu jeffreyk@intra.niddk.nih.gov., Departments of Epidemiology, ogutierrez@uabmc.edu jeffreyk@intra.niddk.nih.gov., Medicine, University of Alabama at Birmingham, Birmingham, Alabama.,
    1. Year: 2019
    2. Date: Dec 6
    3. Epub Date: 2019 11 08
  2. Journal: Clinical journal of the American Society of Nephrology : CJASN
    1. 14
    2. 12
    3. Pages: 1733-1740
  4. Type of Article: Article
  5. ISSN: 1555-9041
  1. Abstract:

    BACKGROUND AND OBJECTIVES: apo L1 (APOL1) nephropathy risk alleles are associated with CKD in blacks. Although APOL1 has innate immune functions, little is known about the association of APOL1 genotypes with risk of infectious outcomes, such as sepsis. The objective of this study was to examine the associations of APOL1 nephropathy risk alleles with risk of sepsis in black adults. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We assessed the association of APOL1 risk alleles with incident sepsis in 10,366 black participants of the Reasons for Geographic and Racial Differences in Stroke study enrolled between 2003 and 2007 with follow-up through December 31, 2012. In Cox models adjusted for demographics, comorbid conditions, and principal components ancestry, we examined the association of APOL1 risk alleles with incident sepsis using recessive (comparing zero or one versus two risk alleles), dominant (zero versus one or two risk alleles), and additive genetic models. We also examined models stratified by diabetes and CKD status. RESULTS: A total of 1320 (13%) participants had two APOL1 risk alleles, 4719 (46%) had one risk allele, and 4327 (42%) participants had zero risk alleles. A total of 306 sepsis events occurred over a median 6.5 years (interquartile range, 4.5-8.1). There were no statistically significant associations of APOL1 genotype with sepsis risk under recessive genetic models. APOL1 genotypes were associated with sepsis risk under dominant (hazard ratio, 1.55; 95% confidence interval, 1.13 to 2.11) and additive (hazard ratio per variant allele copy, 1.25; 95% confidence interval, 1.02 to 1.53) genetic models adjusted for covariates and ancestry. These associations did not vary by diabetes or CKD status (P interaction>0.10 for both). CONCLUSIONS: In community-dwelling black adults, carriage of APOL1 nephropathy risk alleles are common and associated with higher risk of sepsis. Copyright © 2019 by the American Society of Nephrology.

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External Sources

  1. View Full Text
  2. DOI: 10.2215/CJN.04490419
  3. PMID: 31704668
  4. View record in Web of Science®
  5. WOS: 000506176900011
  6. PII : CJN.04490419

Library Notes

  1. Fiscal Year: FY2019-2020
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