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A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma

  1. Author:
    Liu, Jinping
    Tang, Wei
    Budhu, Anuradha
    Forgues, Marshonna
    Hernandez, Maria O
    Candia, Julián
    Kim, Yujin
    Bowman, Elise D
    Ambs, Stefan
    Zhao,Yongmei
    Tran,Bao
    Wu,Xiaolin
    Koh, Christopher
    Surana, Pallavi
    Liang, T Jake
    Guarnera, Maria
    Mann, Dean
    Rajaure, Manoj
    Greten, Tim F
    Wang, Zhanwei
    Yu, Herbert
    Wang, Xin Wei

  2. Author Address

    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Molecular Epidemiology Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA., Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, MD 20892, USA., Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA., Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA., Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: xw3u@nih.gov.,
    1. Year: 2020
    2. Date: JUL 23
    3. Epub Date: 2020 06 09
  2. Journal: Cell
    1. 182
    2. 2
    3. Pages: 317-+
  4. Type of Article: Article
  5. ISSN: 0092-8674
  1. Abstract:

    Hepatocellular carcinoma (HCC) is an aggressive malignancy with its global incidence and mortality rate continuing to rise, although early detection and surveillance are suboptimal. We performed serological profiling of the viral infection history in 899 individuals from an NCI-UMD case-control study using a synthetic human virome, VirScan. We developed a viral exposure signature and validated the results in a longitudinal cohort with 173 at-risk patients who had long-term follow-up for HCC development. Our viral exposure signature significantly associated with HCC status among at-risk individuals in the validation cohort (area under the curve: 0.91 [95% CI 0.87-0.96] at baseline and 0.98 [95% CI 0.97-1] at diagnosis). The signature identified cancer patients prior to a clinical diagnosis and was superior to alpha-fetoprotein. In summary, we established a viral exposure signature that can predict HCC among at-risk patients prior to a clinical diagnosis, which may be useful in HCC surveillance. Published by Elsevier Inc.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.cell.2020.05.038
  3. PMID: 32526205
  4. View record in Web of Science®
  5. WOS: 000552745000006
  6. PII : S0092-8674(20)30671-1

Library Notes

  1. Fiscal Year: FY2019-2020
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