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Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture

  1. Author:
    Shrivastava-Ranjan, Punya
    Lo, Michael K.
    Chatterjee, Payel
    Flint, Mike
    Nichol, Stuart T.
    Montgomery, Joel M.
    O'Keefe,Barry
    Spiropoulou, Christina F.

  2. Author Address

    Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Viral Special Pathogens Branch, Atlanta, GA 30333 USA.NCI, Mol Targets Program, Ctr Canc Res, Frederick, MD 21701 USA.NCI, Div Canc Treatment & Diag, Nat Prod Branch, Dev Therapeut Program, Frederick, MD 21701 USA.
    1. Year: 2020
    2. Date: NOV 4
    3. Epub Date: 2020 11 04
  2. Journal: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
  3. FRONTIERS MEDIA SA,
    1. 10
    2. Pages: 561502
  5. Type of Article: Article
  6. Article Number: 561502
  7. ISSN: 2235-2988
  1. Abstract:

    Andes virus (ANDV) and Sin Nombre virus (SNV), highly pathogenic hantaviruses, cause hantavirus pulmonary syndrome in the Americas. Currently no therapeutics are approved for use against these infections. Griffithsin (GRFT) is a high-mannose oligosaccharide-binding lectin currently being evaluated in phase I clinical trials as a topical microbicide for the prevention of human immunodeficiency virus (HIV-1) infection (ClinicalTrials.gov Identifiers: NCT04032717, NCT02875119) and has shown broad-spectrum in vivo activity against other viruses, including severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, and Nipah virus. In this study, we evaluated the in vitro antiviral activity of GRFT and its synthetic trimeric tandemer 3mGRFT against ANDV and SNV. Our results demonstrate that GRFT is a potent inhibitor of ANDV infection. GRFT inhibited entry of pseudo-particles typed with ANDV envelope glycoprotein into host cells, suggesting that it inhibits viral envelope protein function during entry. 3mGRFT is more potent than GRFT against ANDV and SNV infection. Our results warrant the testing of GRFT and 3mGRFT against ANDV infection in animal models.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/fcimb.2020.561502
  3. PMID: 33251157
  4. PMCID: PMC7671970
  5. View record in Web of Science®
  6. WOS: 000589962100001

Library Notes

  1. Fiscal Year: FY2020-2021
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