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IMPACT OF AGE AND RACE ON HEALTH-RELATED QUALITY OF LIFE OUTCOMES IN PATIENTS UNDERGOING RADICAL PROSTATECTOMY FOR LOCALIZED PROSTATE CANCER

  1. Author:
    Posielski, Natasza
    Frankel, Jason
    Kuo, Huai-Ching
    Ho, On
    Elsamanoudi, Sally
    Nousome,Darryl
    Speir, Ryan
    Stroup, Sean
    Musser, John
    Ernest, Alexander
    Chesnut, Gregory T
    Tausch, Timothy
    Flores, John Paul
    Porter, Christopher

  2. Author Address

    Virginia Mason Hospital and Seattle Medical Center., Virginia Mason Hospital and Seattle Medical Center; Washington St. Louis University., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD; Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD; Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; Madigan Army Medical Center, Tacoma, WA., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; Naval Medical Center, San Diego, CA., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; Tripler Army Medical Center, Honolulu, HI., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; Brooke Army Medical Center, Fort Sam Houston, TX., Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; Walter Reed National Military Medical Center, Bethesda, MD., Virginia Mason Hospital and Seattle Medical Center. Electronic address: Christopher.Porter@virginiamason.org.,
    1. Year: 2021
    2. Date: Aug 21
    3. Epub Date: 2021 08 21
  2. Journal: Urology
  4. Type of Article: Article
  1. Abstract:

    To investigate impact of age and race on health-related quality of life (HRQoL) in men undergoing radical prostatectomy (RP) using a prospectively maintained, racially diverse cohort. The Center for Prostate Disease Research Multicenter National Database was used to identify patients receiving RP from 2007-2017. The Expanded PCa Index Composite and 36 Item Short-Form Health Survey were completed at baseline and regular intervals. Groups were stratified based on age: < 60, 60-70, >70. Longitudinal patterns in HRQoL were assessed using linear regression models, adjusting for baseline HRQoL, demographics, and clinical characteristics. In 626 patients undergoing RP, 278 (44.4%) were < 60, 291 (46.5%) were 60-70, 57 (9.1%) were >70. Older men had worse baseline urinary bother (p< 0.01) and sexual HRQoL (p< 0.01). Baseline urinary function was similar for older and younger men. Post-RP urinary and sexual HRQoL was significantly lower in men >70. However, when adjusting for baseline HRQoL, race, NCCN risk, and comorbidities, no difference was found between age groups in urinary function or bother, or sexual function. Sexual bother was worse in older men until 48 months post-operatively but subsequently improved to levels similar to younger patients. Race independently affected HRQoL outcomes with older African American men reporting worse urinary function and sexual bother. When accounting for baseline HRQoL, age does not independently predict worse HRQoL outcomes. Older and younger men experience similar declines in urinary and sexual domain scores after RP. Our findings may be used to better inform patients regarding their expected post RP HRQoL and guide treatment decision-making. Copyright © 2021 Elsevier Inc. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.urology.2021.07.034
  3. PMID: 34428537
  4. PII : S0090-4295(21)00783-4

Library Notes

  1. Fiscal Year: FY2020-2021
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