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Oral-Gut Microbiome Axis in Gastrointestinal Disease and Cancer

  1. Author:
    Park, Se-Young
    Hwang, Byeong-Oh
    Lim, Mihwa
    Ok, Seung-Ho
    Lee, Sun-Kyoung
    Chun, Kyung-Soo
    Park, Kwang-Kyun
    Hu,Yinling
    Chung, Won-Yoon
    Song, Na-Young
  2. Author Address

    Yonsei Univ, Grad Sch, Dept Appl Life Sci, Seoul 03722, South Korea.Yonsei Univ, Coll Dent, BK21 FOUR Project, Seoul 03722, South Korea.Yonsei Univ, Coll Dent, Dept Oral Biol, Seoul 03722, South Korea.Keimyung Univ, Coll Pharm, Daegu 42601, South Korea.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA.Yonsei Univ, Coll Dent, Dept Oral Biol, Oral Canc Res Inst, Seoul 03722, South Korea.
    1. Year: 2021
    2. Date: May
    3. Epub Date: 2021 Apr 28
  1. Journal: Cancers
  2. MDPI,
    1. 13
    2. 9
  3. Type of Article: Article
  4. Article Number: ARTN 2124
  5. ISSN: 2072-6694
  1. Abstract:

    It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.

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External Sources

  1. DOI: 10.3390/cancers13092124
  2. PMID: 33924899
  3. PMCID: PMC8125773
  4. WOS: 000649861900001

Library Notes

  1. Fiscal Year: FY2020-2021
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