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Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

  1. Author:
    Smith, Steven J.
    Zhao,Xue Zhi
    Passos, Dario Oliveira
    Lyumkis, Dmitry
    Burke,Terrence
    Hughes,Stephen

  2. Author Address

    NCI, HIV Dynam & Replicat Program, Ctr Canc Res, Frederick, MD 21702 USA.NCI, Chem Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA.Salk Inst Biol Studies, Lab Genet, La Jolla, CA 92037 USA.Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA.
    1. Year: 2021
    2. Date: Jan 29
  2. Journal: Viruses (Basel)
  3. MDPI,
    1. 13
    2. 2
  5. Type of Article: Article
  6. Article Number: ARTN 205
  7. ISSN: 1999-4915
  1. Abstract:

    Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation INSTIs are effective but can select for resistant viruses. Recent advances have led to several potent second-generation INSTIs that are effective against both wild-type (WT) HIV-1 integrase and many of the first-generation INSTI-resistant mutants. The emergence of resistance to these new second-generation INSTIs has been minimal, which has resulted in alternative treatment strategies for HIV-1 patients. Moreover, because of their high antiviral potencies and, in some cases, their bioavailability profiles, INSTIs will probably have prominent roles in pre-exposure prophylaxis (PrEP). Herein, we review the current state of the clinically relevant INSTIs and discuss the future outlook for this class of antiretrovirals.

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External Sources

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  2. DOI: 10.3390/v13020205
  3. PMID: 33572956
  4. PMCID: PMC7912079
  5. View record in Web of Science®
  6. WOS: 000623307500001

Library Notes

  1. Open Access Publication
  2. Fiscal Year: FY2020-2021
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