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Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) following investigational therapy in dogs and cats

  1. Author:
    LeBlanc, Amy K.
    Atherton, Matthew
    Bentley, R. Timothy
    Boudreau, C. Elizabeth
    Burton, Jenna H.
    Curran, Kaitlin M.
    Dow, Steven
    Giuffrida, Michelle A.
    Kellihan, Heidi B.
    Mason, Nicola J.
    Oblak, Michelle
    Selmic, Laura E.
    Selting, Kimberly A.
    Singh, Ameet
    Tjostheim, Sonja
    Vail, David M.
    Weishaar, Kristen M.
    Berger,Erika
    Rossmeisl, John H.
    Mazcko, Christina
  2. Author Address

    NCI, NIH, Comparat Oncol Program, Ctr Canc Res, Bethesda, MD 20892 USA.Univ Penn, Sch Vet Med, Dept Biomed Sci, Philadelphia, PA 19104 USA.Purdue Univ, Dept Vet Clin Sci, W Lafayette, IN 47907 USA.Purdue Univ, Ctr Canc Res, W Lafayette, IN 47907 USA.Texas A&M Univ, Dept Small Anim Clin Sci, Coll Vet Med & Biomed Sci, College Stn, TX USA.Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Anim Canc Ctr, Ft Collins, CO 80523 USA.Oregon State Univ, Dept Clin Sci, Carlson Coll Vet Med, Corvallis, OR 97331 USA.Univ Calif Davis, Davis Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95616 USA.Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA.Univ Penn, Sch Vet Med, Dept Clin Sci & Adv Med, Philadelphia, PA 19104 USA.Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA.Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA.Univ Guelph, Ontario Vet Coll, Dept Clin Studies, Guelph, ON, Canada.Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA.Univ Illinois, Coll Vet Med, Dept Vet Clin Sci, Urbana, IL USA.NCI, Frederick Natl Lab Canc Res, Comparat Oncol Program, Bethesda, MD 20892 USA.VA MD Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA USA.
    1. Year: 2021
    2. Date: Jun
    3. Epub Date: 2021 02 18
  1. Journal: VETERINARY AND COMPARATIVE ONCOLOGY
  2. WILEY,
    1. 19
    2. 2
    3. Pages: 311-352
  3. Type of Article: Article
  4. ISSN: 1476-5810
  1. Abstract:

    The updated VCOG-CTCAE v2 guidelines contain several important updates and additions since the last update (v1.1) was released in 2011 and published within Veterinary and Comparative Oncology in 2016. As the Veterinary Cooperative Oncology Group (VCOG) is no longer an active entity, the original authors and contributors to the VCOG-CTCAE v1.0 and v1.1 were consulted for input, and additional co-authors sought for expansion and refinement of the adverse event (AE) categories. VCOG-CTCAE v2 includes expanded neurology, cardiac and immunologic AE sections, and the addition of procedural-specific AEs. It is our intent that, through inclusion of additional authors from ACVIM subspecialties and the American College of Veterinary Surgery, that we can more comprehensively capture AEs that are observed during clinical studies conducted across a variety of disease states, clinical scenarios, and body systems. It is also our intent that these updated veterinary CTCAE guidelines will offer improved application and ease of use within veterinary practice in general, as well as within clinical trials that assess new therapeutic strategies for animals with a variety of diseases. Throughout the revision process, we strived to ensure the grading structure for each AE category was reflective of the decision-making process applied to determination of dose-limiting events. As phase I trial decisions are based on these criteria and ultimately determine the maximally tolerated dose, there is impact on standard dosing recommendations for any new drug registration or application. This document should be updated regularly to reflect ongoing application to clinical studies carried out in veterinary patients.

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External Sources

  1. DOI: 10.1111/vco.12677
  2. PMID: 33427378
  3. PMCID: PMC8248125
  4. WOS: 000619234600001

Library Notes

  1. Fiscal Year: FY2020-2021
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