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Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report

  1. Author:
    Cable, Jennifer
    Weber-Ban, Eilika
    Clausen, Tim
    Walters,Kylie
    Sharon, Michal
    Finley, Daniel J.
    Gu, Yangnan
    Hanna, John
    Feng, Yue
    Martens, Sascha
    Simonsen, Anne
    Hansen, Malene
    Zhang, Hong
    Goodwin, Jonathan M.
    Reggio, Alessio
    Chang, Chunmei
    Ge, Liang
    Schulman, Brenda A.
    Deshaies, Raymond J.
    Dikic, Ivan
    Harper, J. Wade
    Wertz, Ingrid E.
    Thoma, Nicolas H.
    Slabicki, Mikolaj
    Frydman, Judith
    Jakob, Ursula
    David, Della C.
    Bennett, Eric J.
    Bertozzi, Carolyn R.
    Sardana, Richa
    Eapen, Vinay V.
    Carra, Serena

  2. Author Address

    PhD Sci Writer, New York, NY 10022 USA.Swiss Fed Inst Technol, Inst Mol Biol & Biophys, Zurich, Switzerland.Med Univ Vienna, Res Inst Mol Pathol IMP, Vienna, Austria.Med Univ Vienna, Vienna Bioctr, Vienna, Austria.NCI, Ctr Canc Res, Struct Biol Ctr, Protein Proc Sect,NIH, Frederick, MD USA.Weizmann Inst Sci, Dept Bimolecular Sci, Rehovot, Israel.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA.Univ Calif Berkeley, Biol & Innovat Genom Inst, Dept Plant & Microbial, Berkeley, CA 94720 USA.Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA.Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.Univ Vienna, Vienna Bioctr VBC, Max Perutz Labs, Vienna, Austria.Univ Oslo, Inst Basic Med Sci, Dept Mol Med, Oslo, Norway.Univ Oslo, Ctr Canc Cell Reprogramming, Inst Clin Med, Oslo, Norway.Oslo Univ Hosp, Inst Canc Res, Dept Mol Cell Biol, Oslo, Norway.Sanford Burnham Prebys Med Discovery Inst, Program Dev Aging & Regenerat, La Jolla, CA USA.Univ Chinese Acad Scie, Inst Biophys, Coll Life Sciences, CAS Ctr Excellence Biomacromolecules,Natl Lab Bio, Beijing, Beijing, Peoples R China.Casma Therapeut, Cambridge, MA USA.Telethon Inst Genet & Med TIGEM, Pozzuoli, Italy.Univ Calif Berkeley, Mol & Cell Biol, Berkeley, CA 94720 USA.Tsinghua Univ, Peking Univ Joint Ctr Life Sci, Sch Life Sci, State Key Lab Membrane Biol, Beijing, Peoples R China.Max Planck Inst Biochem, Dept Mol Machines & Signaling, Martinsried, Germany.Amgen Inc, Thousand Oaks, CA USA.Goethe Univ, Inst Biochem 2, Sch Med, Frankfurt, Germany.Goethe Univ, Buchmann Inst Mol Life Sci, Frankfurt, Germany.Harvard Med Sch, Blavatn Inst, Dept Cell Biol, Boston, MA 02115 USA.Genentech Inc, Dept Mol Oncol, South San Francisco, CA USA.Genentech Inc, Early Discovery Biochem, South San Francisco, CA USA.Bristol Myers Squibb, Brisbane, CA USA.Friedrich Miescher Inst Biomed Res, Basel, Switzerland.Broad Inst MIT & Harvard, Cambridge, MA USA.Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.German Canc Res Ctr, Div Translat Med Oncol, Heidelberg, Germany.Natl Ctr Tumor Dis NCT, Heidelberg, Germany.Stanford Univ, Biophys Grad Program, Dept Biol, Stanford, CA 94305 USA.Stanford Univ, Dept Genet, Stanford, CA 94305 USA.Biohub, San Francisco, CA USA.SLAC Natl Accelerator Lab, Div CryoEM & Bioimaging, SSRL, Menlo Pk, CA USA.Univ Michigan, Dept Mol Cellular & Dev Biol, Coll Literature Sci & Arts, Ann Arbor, MI 48109 USA.Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany.Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany.Univ Calif San Diego, Div Biol Sci, Sect Cell & Dev Biol, La Jolla, CA 92093 USA.Stanford Univ, Dept Chem, Stanford, CA 94305 USA.Stanford Univ, Stanford ChEM H, Stanford, CA 94305 USA.Howard Hughes Med Inst, Stanford, CA USA.Cornell Univ, Weill Inst Cell & Mol Biol, Ithaca, NY 14853 USA.Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA.Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy.
    1. Year: 2022
    2. Date: Jan
  2. Journal: Annals of the New York Academy of Sciences
  3. Wiley
  5. Type of Article: Article
  6. ISSN: 0077-8923
  1. Abstract:

    Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome-lysosome pathway, must be tightly regulated to ensure proper elimination of misfolded and aggregated proteins and regulate changing protein levels during cellular differentiation, while ensuring that normal proteins remain unscathed. Protein degradation pathways have also garnered interest as a means to selectively eliminate target proteins that may be difficult to inhibit via other mechanisms. On June 7 and 8, 2021, several experts in protein degradation pathways met virtually for the Keystone eSymposium "Targeting protein degradation: from small molecules to complex organelles." The event brought together researchers working in different protein degradation pathways in an effort to begin to develop a holistic, integrated vision of protein degradation that incorporates all the major pathways to understand how changes in them can lead to disease pathology and, alternatively, how they can be leveraged for novel therapeutics.

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External Sources

  1. View Full Text
  2. DOI: 10.1111/nyas.14745
  3. PMID: 35000205
  4. View record in Web of Science®
  5. WOS: 000740430000001

Library Notes

  1. Fiscal Year: FY2021-2022
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