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Thrombin Generation in Trauma Patients: How Do we Navigate Through Scylla and Charybdis?

  1. Author:
    Mitrophanov,Alex
    Vandyck, Kofi
    Tanaka, Kenichi A.

  2. Author Address

    NIH, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.Univ Oklahoma, Dept Anesthesiol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA.
    1. Year: 2022
    2. Date: Jan 24
  2. Journal: Current Anesthesiology Reports
  3. Springer Nature
  5. Type of Article: Article
  6. ISSN: 2167-6275
  1. Abstract:

    Purpose of Review Coagulopathy is a complex pathological condition manifested through the insufficient or excessive tendency to form blood thrombi, which can be caused by trauma and surgery. A promising strategy to mitigate coagulopathy is the balanced restoration of the generation of thrombin - the main enzyme in the blood-coagulation system. We review studies focusing on thrombin, traumatic coagulopathy, and hemostatic balance - a concept aimed to avoid abnormally weak or excessively strong coagulation responses.

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External Sources

  1. View Full Text
  2. DOI: 10.1007/s40140-021-00502-0
  3. View record in Web of Science®
  4. WOS: 000746297200001

Library Notes

  1. Fiscal Year: FY2021-2022
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