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Plasma SARS-CoV-2 RNA levels as a biomarker of lower respiratory tract SARS-CoV-2 infection in critically ill patients with COVID-19

  1. Author:
    Jacobs, Jana L
    Naqvi, Asma
    Shah, Faraaz A
    Boltz,Valerie
    Kearney,Mary
    McVerry, Bryan J
    Ray, Prabir
    Schaefer, Caitlin
    Fitzpatrick, Meghan
    Methé, Barbara
    Lee, Janet S
    Morris, Alison
    Mellors, John W
    Kitsios, Georgios D
    Bain, William

  2. Author Address

    University of Pittsburgh School of Medicine, Department of Medicine, Division of Infectious Diseases, Pittsburgh, PA, USA., Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Veteran 39;s Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA., HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Center for Medicine and the Microbiome, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.,
    1. Year: 2022
    2. Date: May 02
    3. Epub Date: 2022 05 02
  2. Journal: The Journal of Infectious Diseases
  4. Type of Article: Article
  1. Abstract:

    Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19 outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract (LRT) vRNA levels is unclear. We compared plasma and LRT vRNA levels in serially collected samples from mechanically ventilated patients with COVID-19. LRT and plasma vRNA levels were strongly correlated at first sampling (n=33, r=0.83, p< 10-9) and then declined in parallel in available serial samples except in non-survivors who exhibited delayed vRNA clearance in LRT samples. Plasma vRNA measurement may offer a practical surrogate of LRT vRNA burden in critically ill patients, especially early after ICU admission. © Published by Oxford University Press on behalf of Infectious Diseases Society of America and HIV Medicine Association 2022.

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External Sources

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  2. DOI: 10.1093/infdis/jiac157
  3. PMID: 35511031
  4. PII : 6576503

Library Notes

  1. Fiscal Year: FY2021-2022
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