Skip NavigationSkip to Content
Return Return to Search Results

Risk Factors for Ebola Virus Persistence in Semen of Survivors - Liberia

  1. Author:
    Dyal, Jonathan
    Kofman, Aaron [ORCID]
    Kollie, Jomah Z
    Fankhauser, John
    Orone, Romeo
    Soka, Moses J
    Glaybo, Uriah
    Kiawu, Armah
    Freeman, Edna
    Giah, Giovanni
    Tony, Henry D
    Faikai, Mylene
    Jawara, Mary
    Kamara, Kuku
    Kamara, Samuel
    Flowers, Benjamin
    Kromah, Mohammed L
    Desamu-Thorpe, Rodel
    Graziano, James
    Brown, Shelley
    Morales-Betoulle, Maria E
    Cannon, Deborah L
    Su, Kaihong
    Linderman, Susanne L
    Plucinski, Mateusz
    Rogier, Eric
    Bradbury, Richard S
    Secor, W Evan
    Bowden, Katherine E
    Phillips, Christi
    Carrington,Mary
    Park, Yeon-Hwa
    Martin, Maureen P
    Del Pilar Aguinaga, Maria
    Mushi, Robert
    Haberling, Dana L
    Ervin, Elizabeth D
    Klena, John D
    Massaquoi, Moses
    Nyenswah, Tolbert
    Nichol, Stuart T
    Chiriboga, David E
    Williams, Desmond E
    Hinrichs, Steven H
    Ahmed, Rafi
    Vonhm, Benjamin T
    Rollin, Pierre E
    Purpura, Lawrence J
    Choi, Mary J

  2. Author Address

    Epidemic Intelligence Service, CDC, Atlanta, GA, USA., Division of High-Consequence Pathogens and Pathology, CDC, Atlanta, GA, USA., Men 39;s Health Screening Program, Liberia., ELWA Hospital, Samaritan 39;s Purse, Monrovia, Liberia., Office of Public Health Preparedness and Response, CDC, Atlanta, GA, USA., Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA., Emory Vaccine Center, Emory University, Atlanta, GA., Division of Parasitic Diseases and Malaria, CDC, Atlanta, GA, USA., Division of STD Prevention, CDC, Atlanta, GA, USA., Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Ragon Institute of MGH, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Meharry Sickle Cell Center, Department of Internal Medicine, Meharry Medical College, Nashville, TN, USA., Meharry Sickle Cell Center, Department of Obstetrics and Gynecology, Nashville, TN, USA., Ministry of Health, Liberia., University of Massachusetts Medical School, Worcester, MA, USA., Center for Global Health, CDC, Atlanta, GA, USA., National Public Health Institute of Liberia, Monrovia, Liberia.,
    1. Year: 2022
    2. Date: May 27
    3. Epub Date: 2022 05 27
  2. Journal: Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America
  4. Type of Article: Article
  5. Article Number: ciac424
  1. Abstract:

    Long-term persistence of Ebola virus (EBOV) in immunologically-privileged sites has been implicated in recent outbreaks of Ebola Virus Disease (EVD) in Guinea and the Democratic Republic of Congo. This study was designed to understand how the acute course of EVD, convalescence, and host immune and genetic factors may play a role in prolonged viral persistence in semen. A cohort of 131 male EVD survivors in Liberia were enrolled in a case-case study. "Early clearers" were defined as those with two consecutive negative EBOV semen tests by real-time reverse transcriptase polymerase chain reaction (rRT-PCR) at least two weeks apart within 1 year after discharge from the Ebola Treatment Unit (ETU) or acute EVD. "Late clearers" had detectable EBOV RNA by rRT-PCR over one year following ETU discharge or acute EVD. Retrospective histories of their EVD clinical course were collected by questionnaire, followed by complete physical exams and blood work. Compared to early clearers, late clearers were older (median 42.5 years, p?=?0.0001) and experienced fewer severe clinical symptoms (median 2, p?=?0.006). Late clearers had more lens opacifications (OR 3.9, 95%CI 1.1-13.3, p?=?0.03), after accounting for age, higher total serum IgG3 titers (p?=?0.007) and increased expression of the HLA-C*03:04 allele (OR 0.14, 95% CI 0.02-0.70, p?=?0.007). Older age, decreased illness severity, elevated total serum IgG3 and HLA-C*03:04 allele expression may be risk factors for the persistence of EBOV in the semen of EVD survivors. EBOV persistence in semen may also be associated with its persistence in other immunologically protected sites, such as the eye. © Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2022.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/cid/ciac424
  3. PMID: 35639875
  4. PII : 6594055

Library Notes

  1. Fiscal Year: FY2021-2022
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel