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Immune correlates of HIV-1 reservoir cell decline in early-treated infants

  1. Author:
    Hartana, Ciputra Adijaya
    Garcia-Broncano, Pilar
    Rassadkina, Yelizaveta
    Lian, Xiaodong
    Jiang, Chenyang
    Einkauf, Kevin B
    Maswabi, Kenneth
    Ajibola, Gbolahan
    Moyo, Sikhulile
    Mohammed, Terence
    Maphorisa, Comfort
    Makhema, Joseph
    Yuki,Yuko
    Martin,Pat
    Bennett, Kara
    Jean-Philippe, Patrick
    Viard,Mathias
    Hughes, Michael D
    Powis, Kathleen M
    Carrington,Mary
    Lockman, Shahin
    Gao, Ce
    Yu, Xu G
    Kuritzkes, Daniel R
    Shapiro, Roger
    Lichterfeld, Mathias

  2. Author Address

    Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women 39;s Hospital, Boston, MA 02115, USA., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana., Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 20892, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Bennett Statistical Consulting, Inc., Ballston Lake, NY 12019, USA., Division of AIDS, NIAID, NIH, Rockville, MD 20852, USA., Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Harvard Medical School, Boston, MA 02115, USA; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 20892, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Division of Infectious Diseases, Brigham and Women 39;s Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women 39;s Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Harvard Medical School, Boston, MA 02115, USA; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women 39;s Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: mlichterfeld@partners.org.,
    1. Year: 2022
    2. Date: Jul 19
  2. Journal: Cell Reports
    1. 40
    2. 3
    3. Pages: 111126
  4. Type of Article: Article
  5. Article Number: 111126
  1. Abstract:

    Initiation of antiretroviral therapy (ART) in infected neonates within hours after birth limits viral reservoir seeding but does not prevent long-term HIV-1 persistence. Here, we report parallel assessments of HIV-1 reservoir cells and innate antiviral immune responses in a unique cohort of 37 infected neonates from Botswana who started ART extremely early, frequently within hours after birth. Decline of genome-intact HIV-1 proviruses occurs rapidly after initiation of ART and is associated with an increase in natural killer (NK) cell populations expressing the cytotoxicity marker CD57 and with a decrease in NK cell subsets expressing the inhibitory marker NKG2A. Immune perturbations in innate lymphoid cells, myeloid dendritic cells, and monocytes detected at birth normalize after rapid institution of antiretroviral therapy but do not notably influence HIV-1 reservoir cell dynamics. These results suggest that HIV-1 reservoir cell seeding and evolution in early-treated neonates is markedly influenced by antiviral NK cell immune responses. Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.celrep.2022.111126
  3. PMID: 35858580
  4. PII : S2211-1247(22)00932-9

Library Notes

  1. Fiscal Year: FY2021-2022
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