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Oral microbiome and risk of incident head and neck cancer: A nested case-control study

  1. Author:
    Wu, Zeni
    Han, Yongli
    Wan, Yunhu
    Hua, Xing
    Chill, Samantha S
    Teshome, Kedest
    Zhou, Weiyin
    Liu, Jia
    Wu, Dongjing
    Hutchinson,Amy
    Jones,Kristine
    Dagnall,Casey
    Hicks,Belynda
    Liao, Linda
    Hallen-Adams, Heather
    Shi, Jianxin
    Abnet, Christian C
    Sinha, Rashmi
    Chaturvedi, Anil
    Vogtmann, Emily
  2. Author Address

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: zeni.wu@nih.gov., Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Frederick National Lab for Cancer Research, Frederick, MD USA., Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA., Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: emily.vogtmann@nih.gov.,
    1. Year: 2023
    2. Date: Jan 05
    3. Epub Date: 2023 01 05
  1. Journal: Oral Oncology
    1. 137
    2. Pages: 106305
  2. Type of Article: Article
  3. Article Number: 106305
  1. Abstract:

    This nested case-control study in the NIH-AARP Diet and Health Study was carried out to prospectively investigate the relationship of oral microbiome with head and neck cancer (HNC). 56 incident HNC cases were identified, and 112 controls were incidence-density matched to cases. DNA extracted from pre-diagnostic oral wash samples was whole-genome shotgun metagenomic sequenced to measure the overall oral microbiome. ITS2 gene qPCR was used to measure the presence of fungi. ITS2 gene sequencing was performed on ITS2 gene qPCR positive samples. We computed taxonomic and functional alpha-diversity and beta-diversity metrics. The presence and relative abundance of groups of red-complex (e.g., Porphyromonas gingivalis) and/or orange-complex (e.g., Fusobacterium nucleatum) periodontal pathogens were compared between cases and controls using conditional logistic regression models and MiRKAT. Participants with higher taxonomic microbial alpha-diversity had a non-statistically significant decreased risk of HNC. No case-control differences were found for beta diversity by MiRKAT model (all p > 0.05). A greater relative abundance of red-complex periodontal pathogens (OR = 0.51, 95 % CI = 0.26-1.00), orange-complex (OR = 0.38, 95 % CI = 0.18-0.83), and both complexes' pathogens (OR = 0.32, 95 % CI = 0.14-0.75), were associated with reduced risk of HNC. The presence of oral fungi was also strongly associated with reduced risk of HNC compared with controls (OR = 0.39, 95 % CI = 0.17-0.92). Greater taxonomic alpha-diversity, the presence of oral fungi, and the presence or relative abundance of multiple microbial species, including the red- and orange-complex periodontal pathogens, were associated with reduced risk of HNC. Future studies with larger sample sizes are needed to evaluate these associations. Published by Elsevier Ltd.

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External Sources

  1. DOI: 10.1016/j.oraloncology.2022.106305
  2. PMID: 36610232
  3. PII : S1368-8375(22)00595-4

Library Notes

  1. Fiscal Year: FY2022-2023
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