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Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library

  1. Author:
    Martínez-Fructuoso, Lucero
    Arends, S J Ryan
    Freire,Vitor
    Evans,Jason
    DeVries, Sean
    Peyser,Brian [ORCID]
    Akee,Rhone
    Thornburg,Chris [ORCID]
    Kumar,Rohitesh
    Ensel,Susan
    Morgan, Gina M
    McConachie, Grant D [ORCID]
    Veeder, Nathan
    Duncan, Leonard R
    Grkovic,Tanja [ORCID]
    O'Keefe,Barry [ORCID]

  2. Author Address

    Natural Products Branch, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, United States., JMI Laboratories, North Liberty, Iowa 52317, United States., Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States., Department of Chemistry and Physics, Hood College, Frederick, Maryland 21701-8599, United States., Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.,
    1. Year: 2023
    2. Date: May 10
    3. Epub Date: 2023 05 10
  2. Journal: ACS Infectious Diseases
  4. Type of Article: Article
  1. Abstract:

    The continuing emergence of antibiotic-resistant microbes highlights the need for the identification of new chemotypes with antimicrobial activity. One of the most prolific sources of antimicrobial molecules has been the systematic screening of natural product samples. The National Institute of Allergy and Infectious Diseases and the National Cancer Institute here report a large screen of 326,656 partially purified natural product fractions against a panel of four microbial pathogens, resulting in the identification of >3000 fractions with antifungal and/or antibacterial activity. A small sample of these active fractions was further purified and the chemical structures responsible for the antimicrobial activity were elucidated. The proof-of-concept study identified many different chemotypes, several of which have not previously been reported to have antimicrobial activity. The results show that there remain many unidentified antibiotic compounds from nature.

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External Sources

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  2. DOI: 10.1021/acsinfecdis.3c00067
  3. PMID: 37163243

Library Notes

  1. Fiscal Year: FY2022-2023
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