Skip NavigationSkip to Content
Return Return to Search Results

Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation

  1. Author:
    Geffen, Yifat
    Anand, Shankara
    Akiyama, Yo
    Yaron, Tomer M
    Song, Yizhe
    Johnson, Jared L
    Govindan, Akshay
    Babur, Özgün
    Li, Yize
    Huntsman, Emily
    Wang, Liang-Bo
    Birger, Chet
    Heiman, David I
    Zhang, Qing
    Miller, Mendy
    Maruvka, Yosef E
    Haradhvala, Nicholas J
    Calinawan, Anna
    Belkin, Saveliy
    Kerelsky, Alexander
    Clauser, Karl R
    Krug, Karsten
    Satpathy, Shankha
    Payne, Samuel H
    Mani, D R
    Gillette, Michael A
    Dhanasekaran, Saravana M
    Thiagarajan,Mathangi
    Mesri, Mehdi
    Rodriguez, Henry
    Robles, Ana I
    Carr, Steven A
    Lazar, Alexander J
    Aguet, François
    Cantley, Lewis C
    Ding, Li
    Getz, Gad

  2. Author Address

    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA 02115, USA., Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Weill Cornell Medical College, Meyer Cancer Center, New York, NY 10021, USA., Washington University School of Medicine, St. Louis, MO 63110, USA., Department of Computer Science, University of Massachusetts Boston, Boston, MA 02125, USA., Biotechnology and Food Engineering, Lokey Center for Life Science and Engineering, Technion, Israel Institute of Technology, Haifa, Israel., Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Department of Biology, Brigham Young University, Provo, UT 84602, USA., Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA., Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Departments of Pathology 160;& Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA. Electronic address: faguet@illumina.com., Weill Cornell Medical College, Meyer Cancer Center, New York, NY 10021, USA. Electronic address: lewis_cantley@dfci.harvard.edu., Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: lding@wustl.edu., Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: gadgetz@broadinstitute.org.,
    1. Year: 2023
    2. Date: Aug 09
    3. Epub Date: 2023 08 09
  2. Journal: Cell
  4. Type of Article: Article
  1. Abstract:

    Post-translational modifications (PTMs) play key roles in regulating cell signaling and physiology in both normal and cancer cells. Advances in mass spectrometry enable high-throughput, accurate, and sensitive measurement of PTM levels to better understand their role, prevalence, and crosstalk. Here, we analyze the largest collection of proteogenomics data from 1,110 patients with PTM profiles across 11 cancer types (10 from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium [CPTAC]). Our study reveals pan-cancer patterns of changes in protein acetylation and phosphorylation involved in hallmark cancer processes. These patterns revealed subsets of tumors, from different cancer types, including those with dysregulated DNA repair driven by phosphorylation, altered metabolic regulation associated with immune response driven by acetylation, affected kinase specificity by crosstalk between acetylation and phosphorylation, and modified histone regulation. Overall, this resource highlights the rich biology governed by PTMs and exposes potential new therapeutic avenues. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.cell.2023.07.013
  3. PMID: 37582358
  4. PII : S0092-8674(23)00781-X

Library Notes

  1. Fiscal Year: FY2022-2023
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel