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Serum microRNA Profiles and Pathways in Hepatitis B-Associated Hepatocellular Carcinoma: A South African Study

  1. Author:
    Sartorius, Kurt [ORCID]
    Sartorius, Benn
    Winkler,Cheryl
    Chuturgoon, Anil [ORCID]
    Shen,Tsai-Wei
    Zhao,Yongmei [ORCID]
    An,Ping [ORCID]

  2. Author Address

    Faculty of Commerce, Law and Management, University of the Witwatersrand, Johannesburg 2001, South Africa., School of Laboratory Medicine and Molecular Sciences, University of Kwazulu-Natal, Durban 4041, South Africa., Africa Hepatopancreatobiliary Cancer Consortium (AHPBCC), Mayo Clinic, Jacksonville, FL 32224, USA., School of Public Health, University of Queensland, Brisbane, QLD 4102, Australia., Centre for Cancer Research, Basic Research Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institute of Health, Frederick, MD 21701, USA., CCR-SF Bioinformatics Group, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.,
    1. Year: 2024
    2. Date: Jan 12
    3. Epub Date: 2024 01 12
  2. Journal: International Journal of Molecular Sciences
    1. 25
    2. 2
  4. Type of Article: Article
  5. Article Number: 975
  1. Abstract:

    The incidence and mortality of hepatocellular carcinoma (HCC) in Sub-Saharan Africa is projected to increase sharply by 2040 against a backdrop of limited diagnostic and therapeutic options. Two large South African-based case control studies have developed a serum-based miRNome for Hepatitis B-associated hepatocellular carcinoma (HBV-HCC), as well as identifying their gene targets and pathways. Using a combination of RNA sequencing, differential analysis and filters including a unique molecular index count (UMI) = 10 and log fold change (LFC) range > 2: <-0.5 (p < 0.05), 91 dysregulated miRNAs were characterized including 30 that were upregulated and 61 were downregulated. KEGG analysis, a literature review and other bioinformatic tools identified the targeted genes and HBV-HCC pathways of the top 10 most dysregulated miRNAs. The results, which are based on differentiating miRNA expression of cases versus controls, also develop a serum-based miRNA diagnostic panel that indicates 95.9% sensitivity, 91.0% specificity and a Youden Index of 0.869. In conclusion, the results develop a comprehensive African HBV-HCC miRNome that potentially can contribute to RNA-based diagnostic and therapeutic options.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/ijms25020975
  3. PMID: 38256049
  4. PMCID: PMC10815595
  5. PII : ijms25020975

Library Notes

  1. Fiscal Year: FY2023-2024
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