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Tumors and their microenvironments: Learning from pediatric brain pathologies

  1. Author:
    Nussinov, Ruth
    Yavuz, Bengi Ruken
    Jang, Hyunbum

  2. Author Address

    Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; Cancer Innovation Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Electronic address: NussinoR@mail.nih.gov. Cancer Innovation Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Cancer Innovation Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
    1. Year: 2025
    2. Date: Jul
    3. Epub Date: Apr 18
  2. Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
    1. 1880
    2. 3
  4. Type of Article: Review
  5. Article Number: 189328
  1. Abstract:

    Early clues to tumors and their microenvironments come from embryonic development. Here we review the literature and consider whether the embryonic brain and its pathologies can serve as a better model. Among embryonic organs, the brain is the most heterogenous and complex, with multiple lineages leading to wide spectrum of cell states and types. Its dysregulation promotes neurodevelopmental brain pathologies and pediatric tumors. Embryonic brain pathologies point to the crucial importance of spatial heterogeneity over time, akin to the tumor microenvironment. Tumors dedifferentiate through genetic mutations and epigenetic modulations; embryonic brains differentiate through epigenetic modulations. Our innovative review proposes learning developmental brain pathologies to target tumor evolution-and vice versa. We describe ways through which tumor pharmacology can learn from embryonic brains and their pathologies, and how learning tumor, and its microenvironment, can benefit targeting neurodevelopmental pathologies. Examples include pediatric low-grade versus high-grade brain tumors as in rhabdomyosarcomas and gliomas.

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External Sources

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  2. DOI: 10.1016/j.bbcan.2025.189328
  3. PMID: 40254040

Library Notes

  1. Fiscal Year: FY2024-2025
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