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Human papilloma virus (HPV) mediated cancers: an insightful update

  1. Author:
    Baba, Sadaf Khursheed
    Alblooshi, Shahad Shahdad Eissa
    Yaqoob, Reem
    Behl, Shalini
    Al Saleem, Mansour
    Rakha, Emad A
    Malik, Fayaz
    Singh, Mayank
    Macha, Muzafar A
    Akhtar, Mohammed Kalim
    Houry, Walid A
    Bhat, Ajaz A
    Al Menhali, Asma
    Zheng, Zhi-Ming
    Mirza, Sameer [ORCID]

  2. Author Address

    Department of Chemistry, College of Science (COS), United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates., Department of Biology, College of Science (COS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates., Omics Centre of Excellence, M42 Health, Abu Dhabi, United Arab Emirates., Department of Applied Medical Sciences, Applied College, Qassim University, Qassim, Saudi Arabia., Histopathology Department, School of Medicine, University of Nottingham, Nottingham, UK., Department of Pathology, Hamad Medical Corporation, Doha, Qatar., Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, Jammu and Kashmir, 190005, India., Department of Medical Oncology (Lab), Dr. BRAIRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India., Watson-Crick Centre for Molecular Medicine, Islamic University of Science and Technology, Awantipora, Kashmir, 192122, India., Department of Biochemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada., Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada., Metabolic and Mendelian Disorders Clinical Research Program, Precision OMICs Research & Translational Science, Sidra Medicine, Doha, Qatar., Tumor Virus RNA Biology Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Department of Chemistry, College of Science (COS), United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates. sameermirza@uaeu.ac.ae., Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University (UAEU), Al Ain, United Arab Emirates. sameermirza@uaeu.ac.ae.,
    1. Year: 2025
    2. Date: Apr 29
    3. Epub Date: 2025 04 29
  2. Journal: Journal of Translational Medicine
    1. 23
    2. 1
    3. Pages: 483
  4. Type of Article: Review
  5. Article Number: 483
  1. Abstract:

    Human papillomavirus (HPV), a DNA virus, is a well-documented causative agent of several cancers, including cervical, vulvar, vaginal, penile, anal, and head & neck cancers. Major factors contributing to HPV-related cancers include persistent infection and the oncogenic potential of particular HPV genotypes. High-risk HPV strains, particularly HPV-16 and HPV-18, are responsible for over 70% of cervical cancer cases worldwide, as well as a significant proportion of other genital and head and neck cancers. At the molecular level, the oncogenic activity of these viruses is driven by the overexpression of E6 and E7 oncoproteins. These oncoproteins dysregulate the cell cycle, inhibit apoptosis, and promote the accumulation of DNA damage, ultimately transforming normal cells into cancerous ones. This review aims to provide a comprehensive overview of the recent advances in HPV-related cancer biology and epidemiology. The review highlights the molecular pathways of HPV-driven carcinogenesis, focusing on the role of viral oncoproteins in altering host cell targets and disrupting cellular signalling pathways. The review explores the therapeutic potential of these viral proteins, and discusses current diagnostic and treatment strategies for HPV-associated cancers. Furthermore, the review highlights the critical role of HPV in the development of various malignancies, emphasizing the persistent challenges in combating these cancers despite advancements in vaccination and therapeutic strategies. We also emphasize recent breakthroughs in utilizing biomarkers to monitor cancer therapy responses, such as mRNAs, miRNAs, lncRNAs, proteins, and genetic markers. We hope this review will serve as a valuable resource for researchers working on HPV, providing insights that can guide future investigations into this complex virus, which continues to be a major contributor to global morbidity and mortality. © 2025. The Author(s).

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External Sources

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  2. DOI: 10.1186/s12967-025-06470-x
  3. PMID: 40301924
  4. PMCID: PMC12039116

Library Notes

  1. Fiscal Year: FY2024-2025
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