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MHC-I-restricted presentation of HIV-1 virion antigens without viral replication

  1. Author:
    Buseyne, F.
    Le Gall, S.
    Boccaccio, C.
    Abastado, J. P.
    Lifson, J. D.
    Arthur, L. O.
    Riviere, Y.
    Heard, J. M.
    Schwartz, O.

  2. Author Address

    Inst Pasteur, Unite Retrovirus & Transfert Genet, Paris, France. Inst Pasteur, Unite Retrovirus & Transfert Genet, Paris, France. Inst Pasteur, Lab Immunopathol Virale, Paris, France. Inst Cordeliers, ImmunoDesigned Mol Res Labs, Paris, France. NCI, Retroviral Pathogenesis Lab, AIDS Vaccine Program, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA. Schwartz O Inst Pasteur, Unite Retrovirus & Transfert Genet, Paris, France.
    1. Year: 2001
  2. Journal: Nature Medicine
    1. 7
    2. 3
    3. Pages: 344-349
  4. Type of Article: Article
  1. Abstract:

    Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. This exogenous pathway may have a crucial role in the activation of CD8(+) cytotoxic T lymphocytes during human viral infections. We show here that HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T-lymphocyte activation in the absence of viral protein synthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights into how anti-HIV cytotoxic T lymphocytes can be activated and have implications for anti-HIV vaccine design.

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