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Gastrin/cholecystokinin receptor type B expression in human colon tumors

  1. Author:
    Tarasova, N. I.
    Tarm, K. B.
    Farnsworth, D. W.
    Michejda, C. J.
    1. Year of Conference: 1997
  2. Conference Name: Annual Meeting of the American Association for Cancer Research
    1. 38
    2. Pages: A770
  4. Type of Work: Meeting Abstract
  1. Abstract:

    Gastrointestinal hormone gastrin is involved in the control of gastric and colonic mucosal growth and stimulates proliferation of gastrointestinal cancer cells in vitro. However, the role of elevated levels of gastrin in the promotion of tumor growth is hotly debated. The only well characterized and cloned receptor for gastrin is cholecystokinin receptor type B (CCKBR). In order to evaluate the role of CCKBR in the progression of tumors, we have studied expression of the receptor in 61 formaldehyde fixed surgical preparations of human colon tumors by immunohistochemistry. Specific rabbit polyclonal and mouse monoclonal antibodies to the receptor were used in the study. About a half (43%) of the tumors were positive for CCKBR. While 72% of well differentiated tumors were positive, only 27% of poorly differentiated tumors expressed the receptor. The majority (86%) of rectal tumors were receptor negative. Other than that, there was no correlation between receptor expression and tumor localization or tumor invasiveness in our sample. In nude mice, elevation of gastrin levels by injection of omeprazole had no effect on the growth of implanted NIH/3T3 cells transfected with human CCKBR. Thus the presence of CCKBR in tumors cannot serve as an indicator of the potential growth promoting effects of gastrin.

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