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In vivo modulation of ETS genes induced by electromagnetic fields

  1. Author:
    Mucci, N.
    Ianni, A.
    Ursini, C. L.
    Arzani, D.
    Bhat, N. K.
    Navarra, P.
    Romano-Spica, V.
  2. Author Address

    Univ Sacred Heart, Inst Hyg & Publ Hlth, Lgo F Vito, I-00168 Rome, Italy. Univ Sacred Heart, Inst Hyg, I-00168 Rome, Italy. Univ Sacred Heart, Inst Pharmacol, I-00168 Rome, Italy. ISPESL, Dept Occupat Med, Rome, Italy. NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp Inc, Recombinant DNA Lab, Frederick, MD 21702 USA. Romano-Spica V Univ Sacred Heart, Inst Hyg & Publ Hlth, Lgo F Vito, I-00168 Rome, Italy.
    1. Year: 2001
  1. Journal: In Vivo
    1. 15
    2. 6
    3. Pages: 489-494
  2. Type of Article: Article
  1. Abstract:

    We have previously shown that electromagnetic field (EMF) exposure induces ETS1 oncogene overexpression it? different cell lines. In order to investigate in vivo EMF effects, BALB/c mice were exposed at different times to 50 MHz radiation, modulated (80%) at 16 Hz. The exposed and control animals were sacrificed and the spleen excised for rt-pcr and western blot analysis. We observed an increase in ETS1 mRNA and protein expression, but a decrease in ETS2 protein levels. Preliminary results from this experimental model show in vivo evidence of the effect of EMF on ETS oncogene expression.

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