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Identification of Ccr8 - a Human Monocyte and Thymus Receptor For the Cc Chemokine I-309

  1. Author:
    Tiffany, H. L.
    Lautens, L. L.
    Gao, J. L.
    Pease, J.
    Locati, M.
    Combadiere, C.
    Modi, W.
    Bonner, T. I.
    Murphy, P. M.

  2. Author Address

    Murphy PM NIAID HOST DEF LAB NIH BLDG 10 ROOM 11N113 BETHESDA, MD 20892 USA NIAID HOST DEF LAB NIH BETHESDA, MD 20892 USA NIMH GENET SECT BETHESDA, MD 20892 USA UNIV SHEFFIELD KREBS INST DEPT MOL BIOL & BIOTECHNOL SHEFFIELD S10 2TN S YORKSHIRE ENGLAND NCI FREDERICK CANC RES & DEV CTR DYNCORP BIOL CARCINOGENESIS & DEV PROGRAM FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Experimental Medicine
    1. 186
    2. 1
    3. Pages: 165-170
  4. Type of Article: Article
  1. Abstract:

    The human CC chemokine 1-309 is a potent monocyte chemoattractant and inhibits apoptosis in thymic cell lines. Here, we identify a specific human 1-309 receptor, and name it CCR8 according to an accepted nomenclature system. The receptor has seven predicted transmembrane domains, is expressed constitutively in monocytes and thymus, and is encoded by a previously reported gene of previously unknown function named, alternatively, CY6, TER1, and CKR-L1. After transfection with the CY6 open reading frame, a mouse pre-B cell line exhibited calcium flux and chemotaxis in response to 1-309 (EC50 = 2 nM for each), whereas 20 other chemokines were inactive. Signaling was sensitive to pertussis toxin, suggesting coupling to a Gi-type G protein. These properties parallel those of endogenous 1-309 receptors expressed in an HL-60 clone 15 cell line model. The apparent monogamous relationship between I-309 and CCR8 is unusual among known CC chemokines and known CC chemokine receptors. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis. [References: 29]

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