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Lymphocide: Cytokines and the control of lymphoid homeostasis

  1. Author:
    Khaled, A. R.
    Durum, S. K.

  2. Author Address

    NCI, Mol Immunoregulat Lab, Canc Res Ctr, Frederick, MD 21702 USA NCI, Mol Immunoregulat Lab, Canc Res Ctr, Frederick, MD 21702 USA Durum SK NCI, Mol Immunoregulat Lab, Canc Res Ctr, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Nature Reviews Immunology
    1. 2
    2. 11
    3. Pages: 817-830
  4. Type of Article: Review
  1. Abstract:

    In a human, about 10(11) excess peripheral lymphocytes die every day. This death process maintains a constant lymphocyte population size in the face of a continuous influx of new lymphocytes and the homeostatic proliferation of old ones. Death is triggered when a lymphocyte fails to acquire signals from survival factors, the availability of which, therefore, determines the size of the pool of lymphocytes. A lymphocyte acquires survival signals through receptors for cytokines, antigens, hormones and probably other extracellular factors. Here, we discuss current concepts of the intracellular signalling pathways for survival versus death that establish cytokine-regulated lymphocyte homeostasis.

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