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Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration

  1. Author:
    Dorshkind, K.
    Welniak, L.
    Gault, R. A.
    Hixon, J.
    Montecino-Rodriguez, E.
    Horseman, N. D.
    Gertner, J. M.
    Murphy, W. J.

  2. Author Address

    Univ Nevada, Sch Med, Dept Microbiol, MS320, Reno, NV 89557 USA Univ Nevada, Sch Med, Dept Microbiol, Reno, NV 89557 USA Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA NCI, Frederick, MD 21702 USA Univ Cincinnati, Dept Mol & Cellular Physiol, Cincinnati, OH USA Serono Inc, Rockland, MA 02370 USA Murphy WJ Univ Nevada, Sch Med, Dept Microbiol, MS320, Reno, NV 89557 USA
    1. Year: 2003
  2. Journal: Clinical Immunology
    1. 109
    2. 2
    3. Pages: 197-202
  4. Type of Article: Article
  1. Abstract:

    Initial studies on T cell development in the Snell Dwarf (dw/dw) strain of mice, which are deficient in the production of anterior pituitary hormones, have been interpreted to indicate a clear dependence of T cell development on endocrine system-derived factors. However, normal thymopoiesis in this strain has also been reported. The aim of the present study was to reconcile these contradictory data in order to define the role of anterior pituitary hormones in the thymus. The results indicated that if female dw/dw mice are housed together with their normal-sized littermates, thymic cellularity and the frequency of CD4(+)CD8(+) thymocytes are markedly reduced. However, administration of growth hormone could reverse these decreases seen in the double-positive T progenitor cells. Taken together, the data indicate that stress is the unifying parameter that can explain the disparate dw/dw mouse literature and suggest that endocrine effects on the T cell development can best be understood by interpreting the literature in this context. (C) 2003 Elsevier Inc. All rights reserved.

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