Skip NavigationSkip to Content
Return Return to Search Results

Antibody reactivity to latent and lytic antigens to human herpesvirus-8 in longitudinally followed homosexual men

  1. Author:
    Biggar, R. J.
    Engels, E. A.
    Whitby, D.
    Kedes, D. H.
    Goedert, J. J.

  2. Author Address

    NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,Rm 8014, Bethesda, MD 20852 USA NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20852 USA NCI, Viral Epidemiol Lab, SAIC Frederick, Frederick, MD 21701 USA Univ Virginia Htlh Syst, Dept Microbiol, Charlottesville, VA USA Univ Virginia Htlh Syst, Dept Internal Med, Charlottesville, VA USA Biggar RJ NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,Rm 8014, Bethesda, MD 20852 USA
    1. Year: 2003
  2. Journal: Journal of Infectious Diseases
    1. 187
    2. 1
    3. Pages: 12-18
  4. Type of Article: Article
  1. Abstract:

    Tests for human herpesvirus-8 (HHV-8) often disagree on which individuals are infected. To evaluate HHV-8 antibody changes over many years, 245 homosexual men enrolled in a prospective study between 1982 and 1999 were studied. Samples collected annually were evaluated by immunofluorescence to HHV-8 latent nuclear antigen and by an ELISA for antibody against the HHV-8 lytic antigen K8.1. When positive, samples from most subjects were persistently reactive in both assays. Titers to both lytic and latent antibodies increased for many years, usually in parallel, and were higher in human immunodeficiency virus- infected men. The increasing titers and expanding epitope recognition suggest ongoing, low-grade replication of HHV-8. Use of multiple assays is important in determining prevalence in asymptomatic populations. Because persons with more advanced infections have higher antibody titers, they are easier to detect, which may skew our understanding of the epidemiology of HHV-8.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel