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Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

  1. Author:
    Wiltshire, T.
    Pletcher, M. T.
    Batalov, S.
    Barnes, S. W.
    Tarantino, L. M.
    Cooke, M. P.
    Wu, H.
    Smylie, K.
    Santrosyan, A.
    Copeland, N. G.
    Jenkins, N. A.
    Kalush, F.
    Mural, R. J.
    Glynne, R. J.
    Kay, S. A.
    Adams, M. D.
    Fletcher, C. F.

  2. Author Address

    Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Scripps Res Inst, San Diego, CA 92121 USA Phenomix, San Diego, CA 92121 USA Seqeunom Inc, San Diego, CA 92121 USA NCI, Frederick, MD 21702 USA Celera Genom, Rockville, MD 20850 USA Wiltshire T Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
    1. Year: 2003
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 100
    2. 6
    3. Pages: 3380-3385
  4. Type of Article: Article
  1. Abstract:

    The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.

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