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Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection

  1. Author:
    Martin, M. P.
    Lederman, M. M.
    Hutcheson, H. B.
    Goedert, J. J.
    Nelson, G. W.
    van Kooyk, Y.
    Detels, R.
    Buchbinder, S.
    Hoots, K.
    Vlahov, D.
    O'Brien, S. J.
    Carrington, M.

  2. Author Address

    NCI, SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA. NCI, Lab Genom Divers, Frederick, MD 21702 USA. NCI, Div Canc Epidemiol & Genet, Viral Epidemiol Branch, Bethesda, MD 20892 USA. Case Western Reserve Univ, Univ Hosp, Ctr AIDS Res, Cleveland, OH 44106 USA. Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol, Amsterdam, Netherlands. Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA. San Francisco Dept Publ Hlth, San Francisco, CA USA. Univ Texas, Hlth Sci Ctr, Gulf States Hemophilia Ctr, Houston, TX USA. New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY USA Carrington, M, NCI, SAIC Frederick, Basic Res Program, POB B, Frederick, MD 21702 USA
    1. Year: 2004
    2. Date: DEC
  2. Journal: Journal of Virology
    1. 78
    2. 24
    3. Pages: 14053-14056
  4. Type of Article: Article
  1. Abstract:

    There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested

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External Sources

  1. View record in Web of Science®
  2. WOS: 000225409900065

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