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Identification and comparative expression analyses of Daam genes in mouse and Xenopus

  1. Author:
    Nakaya, M. A.
    Habas, R.
    Biris, K.
    Dunty, W. C.
    Kato, Y.
    He, X.
    Yamaguchi, T. P.

  2. Author Address

    NCI, Canc Res Ctr, Canc & Dev Biol Lab, NIH, Frederick, MD 21702 USA. Harvard Univ, Childrens Hosp, Sch Med, Div NeurosciDept Neurol, Boston, MA 02115 USA. NICHHD, Mol Genet Lab, Bethesda, MD 20892 USA Yamaguchi, TP, NCI, Canc Res Ctr, Canc & Dev Biol Lab, NIH, 1050 Boyles St,Bldg 539,Rm 218, Frederick, MD 21702 USA
    1. Year: 2004
    2. Date: NOV
  2. Journal: Gene Expression Patterns
    1. 5
    2. 1
    3. Pages: 97-105
  4. Type of Article: Article
  1. Abstract:

    During vertebrate embryogenesis, secreted Writ molecules regulate cell fates by signaling through the canonical pathway mediated by beta-catenin, and regulate planar cell polarity (PCP) and convergent extension movements through alternative pathways. The phosphoprotein Dishevelled (Dsh/Dvl) is a Wnt signal transducer thought to function in all Wnt signaling pathways. A recently identified member of the Formin family, Daarn (Dishevelled-associated activator of morphogenesis), regulates the morphogenetic movements of vertebrate gastrulation in a Wnt-dependent manner through direct interactions with Dsh/Dvl and RhoA. We describe two mouse Daam cDNAs, mDaam1 and mDaam2, which encode proteins characterized by highly conserved formin homology domains and which are expressed in complementary patterns during mouse development. Cross-species comparisons indicate that the expression domains of Xenopus Daam1 (XDaam1) mirror mDaam1 expression. Our results demonstrate that Daams are expressed in tissues known to require Writs and are consistent with Daams being effectors of Wnt signaling during vertebrate development. (C) 2004 Elsevier B.V. All rights reserved

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External Sources

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  2. DOI: 10.1016/j.modgep.2004.06.001
  3. View record in Web of Science®
  4. WOS: 000225368000013

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