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Secondary metabolites of Phlomis viscosa and their biological activities

  1. Author:
    Calis, I.
    Kirmizibekmez, H.
    Beutler, J. A.
    Donmez, A. A.
    Yalcin, F. N.
    Kilic, E.
    Ozalp, M.
    Ruedi, P.
    Tasdemir, D.

  2. Author Address

    Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey. NCI, Mol Targets Dev Program, Frederick, MD 21702 USA. Hacettepe Univ, Fac Sci, Dept Biol, TR-06532 Ankara, Turkey. Hacettepe Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-06100 Ankara, Turkey. Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland Kirmizibekmez, H, Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey
    1. Year: 2005
  2. Journal: Turkish Journal of Chemistry
    1. 29
    2. 1
    3. Pages: 71-81
  4. Type of Article: Article
  1. Abstract:

    Further phytochemical studies on the aerial parts of Phlomis viscosa (Lamiaceae) led to the isolation of 24 compounds: 3 iridoid glycosides, 10 phenylethanoid glycosides, a megastigmane glycoside and a hydroquinone glycoside, as well as 2 lignan glucosides and 7 neolignan glucosides, I of which is new (17b). Compound 17b was obtained is a minor component of an inseparable mixture (2:1) of 2 neolignan glucosides (17a/b), and characterized as 3',4-O-dimethylcedrusin 9-O-beta-glucopyranoside. Full NMR data of the known 8-O-4' neolignan glucoside, etythro-1-(4-O-,beta-glucopyranosyl-3-methoxyphenyl)-2-{2-methoxyl-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol (18) are also reported. All isolated compounds were screened for cell growth inhibition versus 3 tumor cell lines (MCF7, NCI-H460, and SF-268) and several phenylethanoid glycosides were found to possess weak antitumoral activity. The phenylethanoid glycosides were also evaluated for their free radical (DPPH) scavenging, antibacterial and antifungal activities. The free radical (DPPH) scavenging activities of verbascoside (4), isoacteoside (5), forsythoside B (10), myricoside (13) and samioside (14) were found to be comparable to that of dl-alpha-tocopherol. Compounds 4, 5, 10 and 14 (MIC: 500 mu g/mL) as well as Leucosceptoside A (8) and 13 (MIC:1000 mu g/mL) showed very weak activity against Gram (+) bacteria

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  1. View record in Web of Science®
  2. WOS: 000227640300009

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