Skip NavigationSkip to Content
Return Return to Search Results

P205, A potential, tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation

  1. Author:
    Asefa, B.
    Dermott, J. M.
    Kaldis, P.
    Stefanisko, K.
    Garfinkel, D. J.
    Keller, J. R.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Canc Res Ctr, SAIC Frederick Ins,Basic Res Program, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Canc Res Ctr, Mol Immunoregulat Lab, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Canc Res Ctr, Mouse Canc Genet Program, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Canc Res Ctr, SAIC Frederick Inc,Basic Res Program, Frederick, MD 21702 USA.;Keller, JR, NCI, Frederick Canc Res & Dev Ctr, Canc Res Ctr, SAIC Frederick Ins,Basic Res Program, Bldg 560,Room 31-56, Frederick, MD 21702 USA.;kellerj@ncifcrf.gov
    1. Year: 2006
    2. Date: Feb
  2. Journal: Febs Letters
    1. 580
    2. 5
    3. Pages: 1205-1214
  4. Type of Article: Article
  5. ISSN: 0014-5793
  1. Abstract:

    p205 is a member of the interferon-inducible p200 family of proteins that regulate cell proliferation. Over-expression of p205 inhibits cell growth, although its mechanism of action is currently unknown. Therefore, we evaluated the effect of p205 on the p53 and Rb-dependent pathways of cell cycle regulation. p205 expression results in elevated levels of p21, and activates the p21 promoter in vitro in a p53-dependent manner. In addition, p205 induces increased expression of Rb, and binds directly to Rb and p53. Interestingly, p205 also induces growth inhibition independent of p53 and Rb by delaying G21M progression in proliferating cells, and is a substrate for Cdk2 kinase activity. Finally, we have identified other binding partners of p205 by a yeast two-hybrid screen, including the paired homeodomain protein HoxB2. Taken together, our results indicate that p205 induces growth arrest by interaction with multiple transcription factors that regulate the cell cycle, including but not entirely dependent on the Rb- and p53-mediated pathways of growth inhibition. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.febslet.2006.01.032
  3. View record in Web of Science®
  4. WOS: 000235597700003

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel