Skip NavigationSkip to Content
Return Return to Search Results

Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaques

  1. Author:
    Gomez-Roman, V. R.
    Grimes, G. J.
    Potti, G. K.
    Peng, B.
    Demberg, T.
    Gravlin, L.
    Treece, J.
    Pal, R.
    Lee, E. M.
    Alvord, W. G.
    Markham, P. D.
    Robert-Guroff, M.

  2. Author Address

    NCI, NIH, Vaccine Branch, Bethesda, MD 20892 USA. NIH, Ctr Clin, Dept Pharm, Bethesda, MD 20892 USA. Adv BioSci Labs Inc, Kensington, MD 20895 USA. NCI, Data Management Serv, Frederick, MD 21702 USA.;Robert-Guroff, M, NCI, NIH, Vaccine Branch, Bethesda, MD 20892 USA.;guroffm@exchange.nih.gov
    1. Year: 2006
    2. Date: Jun
  2. Journal: Vaccine
    1. 24
    2. 23
    3. Pages: 5064-5072
  4. Type of Article: Article
  5. ISSN: 0264-410X
  1. Abstract:

    Although replication-competent adenovirus (Ad) vectors are promising in AIDS vaccine design, their safety in immune compromised hosts is unknown. To initially address this question, enteric-coated tablets containing a replicating Ad vector were orally administered to SHIV and SIV-infected rhesus macaques with normal, intermediate or low CD4 T cell counts and stable disease. The vector was detected within a week after tablet administration in stools of all animals but not in nasal secretions, indicating no spread of virus to the upper respiratory tract. CD4 T cell counts and viral loads remained stable in all animals and no signs of fever, weight loss, or other clinical symptoms of Ad-induced disease were observed during 10 weeks of follow-up. Oral delivery of the replicating Ad vector was safe and well tolerated by SHIV- and SIV-infected hosts. Oral enteric-coated tablets may prove safe for administering replicating Ad-vectored vaccines in areas with high HIV prevalence. Published by Elsevier Ltd.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.vaccine.2006.03.048
  3. View record in Web of Science®
  4. WOS: 000238557500021

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel