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Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones

  1. Author:
    Yakar, S.
    Nunez, N. P.
    Pennisi, P.
    Brodt, P.
    Sun, H.
    Fallavollita, L.
    Zhao, H.
    Scavo, L.
    Novosyadlyy, R.
    Kurshan, N.
    Stannard, B.
    East-Palmer, J.
    Smith, N. C. P.
    Perkins, S. N.
    Fuchs-Young, R.
    Barrett, J. C.
    Hursting, S. D.
    LeRoith, D.

  2. Author Address

    CUNY Mt Sinai Sch Med, Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA. NIDDKD, Diabet Branch, NIH, Bethesda, MD 20892 USA. NCI, Nutr & Mol Carcinogenesis Sect, Lab Biosyst & Canc, NIH, Bethesda, MD 20892 USA. McGill Univ, Royal Victoria Hosp, Ctr Hlth, Dept Med, Montreal, PQ H3A 1A1, Canada. McGill Univ, Royal Victoria Hosp, Ctr Hlth, Dept Surg, Montreal, PQ H3A 1A1, Canada. NCI, Basic Res Program, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21702 USA. Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Smithville, TX 78957 USA.;Yakar, S, CUNY Mt Sinai Sch Med, Dept Med, Div Endocrinol Diabet & Bone Dis, 1 Gustave L Levy Pl, New York, NY 10029 USA.;shoshana.yakar@mssm.edu
    1. Year: 2006
    2. Date: Dec
  2. Journal: Endocrinology
    1. 147
    2. 12
    3. Pages: 5826-5834
  4. Type of Article: Article
  5. ISSN: 0013-7227
  1. Abstract:

    Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

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External Sources

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  2. DOI: 10.1210/en.2006-0311
  3. View record in Web of Science®
  4. WOS: 000242047200036

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