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Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women

  1. Author:
    Garcia-Pineres, A. J.
    Hildesheim, A.
    Herrero, R.
    Trivett, M.
    Williams, M.
    Atmetlla, I.
    Ramirez, M.
    Villegas, M.
    Schiffman, M.
    Rodriguez, A. C.
    Burk, R. D.
    Hildesheim, M.
    Freer, E.
    Bonilla, J.
    Bratti, C.
    Berzofsky, J. A.
    Pinto, L. A.
  2. Author Address

    Sci Applicat Int Corp Frederick Inc, HPV Immunol Lab, Natl Canc Inst Frederick, Frederick, MD 21702 USA. NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. NCI, Vaccine Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. Med Res Solut, Bethesda, MD USA. Univ Costa Rica, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica. Univ Costa Rica, Ctr Investigac Estruct Microscop, San Jose, Costa Rica. Univ Costa Rica, Ctr Investigac Biol Celular & Mol, San Jose, Costa Rica. Albert Einstein Coll Med, Bronx, NY 10467 USA.;Pinto, LA, Sci Applicat Int Corp Frederick Inc, HPV Immunol Lab, Natl Canc Inst Frederick, Bldg 469,Room 120, Frederick, MD 21702 USA.;lpinto@ncifcrf.gov
    1. Year: 2006
    2. Date: Nov
  1. Journal: Cancer Research
    1. 66
    2. 22
    3. Pages: 11070-11076
  2. Type of Article: Article
  3. ISSN: 0008-5472
  1. Abstract:

    The development of cervical cancer and its precursors are linked to persistent infection with oncogenic types of human papillomavirus (HPV). Host immune responses seem to be determinants of risk for this disease. However, little is known about the immunologic determinants of HPV persistence. Here, we examined the association between lymphoproliferative responses to antigens/mitogens and persistent HPV infection in women older than 45 years. Women included in this study were participants in a 10,000-woman population-based cohort study of cervical neoplasia in Costa Rica. Women older than 45 years and HPV DNA positive at a screening visit were selected as cases (n = 283). We selected a comparably sized control group of HPV DNA-negative women, matched to cases on age and time since enrollment (n = 261). At an additional clinical visit, women were cytologically and virologically rescreened, and cervical and blood specimens were collected. Proliferative responses to phytohemagglutinin (PHA), influenza virus (Flu), and HPV16 virus-like particle (VLP) were lower among women with persistent HPV infection [median counts per minute (cpm): 72,849 for PHA, 1,241 for Flu, and 727 for VLP] than for the control group (median cpm: 107,049 for PHA, 2,111 for Flu, and 2,068 for VLP). The decreases were most profound in women with long-term persistence and were only observed for the oldest age group ( >= 65 years). Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect.

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External Sources

  1. DOI: 10.1158/0008-5472.can-06-2034
  2. WOS: 000242264400054

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