Skip NavigationSkip to Content
Return Return to Search Results

Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma Study

  1. Author:
    Purdue, M. P.
    Lan, Q.
    Kricker, A.
    Grulich, A. E.
    Vajdic, C. M.
    Turner, J.
    Whitby, D.
    Chanock, S.
    Rothman, N.
    Armstrong, B. K.

  2. Author Address

    NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA. Univ Sydney, Sydney, NSW 2006, Australia. Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia. St Vincents Hosp, Sydney, NSW 2010, Australia. NCI, Viral Epidemiol Sect, AVP, SAIC, Frederick, MD 21701 USA. NCI, Core Genotyping Facil, Gaithersburg, MD USA.;Purdue, MP, NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS 8121,MSC 7240, Rockville, MD 20892 USA.;purduem@mail.nih.gov
    1. Year: 2007
    2. Date: Mar
  2. Journal: Carcinogenesis
    1. 28
    2. 3
    3. Pages: 704-712
  4. Type of Article: Article
  5. ISSN: 0143-3334
  1. Abstract:

    Recent findings suggest that genetic polymorphisms in TNF and IL10 are associated with an increased risk of non-Hodgkin lymphoma (NHL), particularly for diffuse large B-cell lymphoma (DLBCL). To further investigate the contribution of common genetic variation in key cytokine and innate immunity genes to the etiology of NHL, we genotyped participants in a case-control study of NHL conducted in Australia (545 cases, 498 controls). We investigated 36 single nucleotide polymorphisms in IL10, TNF and 21 other immune function genes. We observed an elevated risk of DLBCL with the IL10 -3575T > A polymorphism [TA genotype: odds ratio (OR) = 1.32, 95% confidence interval (CI) = 0.86-2.02; AA, OR = 1.84, 95% CI = 1.10-3.08; trend test, P = 0.02]. Our most noteworthy TNF finding was an association between -857C > T and a decreased risk of NHL (CT or TT, OR = 0.59, 95% CI = 0.42-0.84, P = 0.003) and particularly follicular lymphoma (OR = 0.40, 95% CI = 0.23-0.68, P = 0.0009). Additionally, TNF -863C > A was associated with an elevated risk of DLBCL (CA, OR = 1.45, 95% CI = 0.95-2.21; AA, OR = 2.06, 95% CI = 0.88-4.83; trend test, P = 0.02). Our findings offer further evidence that variation in the IL10 and TNF loci influences NHL risk. Additional studies are needed to clarify the genetic and biologic basis for these relationships.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/carcin/bgl200
  3. View record in Web of Science®
  4. WOS: 000245351100023

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel